Evolvulins I and II, Resin Glycosides with a Trihydroxy Aglycone Unit from Evolvulus alsinoides

Evolvulins I and II (1 and 2), representing a new class of resin glycosides with an unprecedented trihydroxy aglycone unit, 3S,11R,14R-trihydroxyhexadecanoic acid (4), were isolated from the whole plants of Evolvulus alsinoides. Their structures were thoroughly characterized by extensive spectroscop...

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Bibliographic Details
Published in:Organic letters 2019-08, Vol.21 (16), p.6548-6551
Main Authors: Fan, Bo-Yi, Lu, Yun, Yang, Min, Li, Jian-Lin, Chen, Guang-Tong
Format: Article
Language:English
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Summary:Evolvulins I and II (1 and 2), representing a new class of resin glycosides with an unprecedented trihydroxy aglycone unit, 3S,11R,14R-trihydroxyhexadecanoic acid (4), were isolated from the whole plants of Evolvulus alsinoides. Their structures were thoroughly characterized by extensive spectroscopic analyses as well as chemical evidence. Compound 1 exhibited the most potent cytotoxic activity against MCF-7 cells, with an IC50 value of 3.12 μM.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.9b02492