Synthesis, characterization and pharmacological potential of green synthesized copper nanoparticles

• Published in: Bioprocess and biosystems engineering 2019-11, Vol.42 (11), p.1769-1777
• Main Authors: Thiruvengadam, Muthu, Chung, Ill-Min, Gomathi, Thandapani, Ansari, Mohammad Azam, Gopiesh Khanna, Venkatesan, Babu, Vaishnavi, Rajakumar, Govindasamy
• Format: Article
• Language: English
• Subjects: Acetic acid; Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Anti-inflammatory agents; Anti-Inflammatory Agents - chemical synthesis; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - pharmacology; Antioxidants; Antioxidants - chemical synthesis; Antioxidants - chemistry; Antioxidants - pharmacology; Bacteria; Biotechnology; Chemistry; Chemistry and Materials Science; Copper; Copper - chemistry; Copper - pharmacology; Denaturation; Diabetes mellitus; Environmental Engineering/Biotechnology; Flowers; Flowers - chemistry; Food Science; Fourier transforms; Gram-positive bacteria; Green Chemistry Technology; Hypoglycemic Agents - chemical synthesis; Hypoglycemic Agents - chemistry; Hypoglycemic Agents - pharmacology; In vivo methods and tests; Industrial and Production Engineering; Industrial Chemistry/Chemical Engineering; Inflammation; Infrared spectroscopy; Metal Nanoparticles - chemistry; Millettia - chemistry; Nanoparticles; Nitric oxide; Particle Size; Pharmacology; Plant Extracts - chemistry; Research Paper; Scavenging; Spectroscopy; Spectrum analysis; Surface plasmon resonance; Synthesis; Visible spectrum
• ISSN: 1615-7591; 1615-7605
• DOI: 10.1007/s00449-019-02173-y

The phenomenal and astonishing properties and their different application in the field of pharmaceutical made copper nanoparticles (Cu-NPs) to be in the spotlight of the researcher's focus. In the present study, copper nanoparticles were biologically synthesized with the aqueous extract of the flower Millettia pinnata , and their corresponding characteristics were studied using UV–visible spectroscopy, XRD, FT-IR, SEM, TEM, and SAED analysis. Copper acetate was reduced to copper nanoparticles and is confirmed by UV–visible spectrophotometer analysis. The maximum absorption occurring at 384 nm at the visible spectrum of UV rays confirms the surface plasmon resonance of the nanoparticles. The result of the FTIR spectroscopy analysis of the nanoparticles complements the involvement of organic mioties of the flower extract in the synthesis. The synthesized particles were extremely durable, spherical with the average particle size in the range of 23 ± 1.10 nm. The Cu-NPs exhibited greater inhibition on DPPH radical and nitric oxide scavenging activities. The biologically synthesized Cu-NPs was receptive to the Gram-negative and Gram-positive bacteria as well. The Cu-NPs exhibited strong anti-inflammatory activity using albumin denaturation and membrane stabilization. The present study is the first effort done to synthesize of Cu-NPs from the extract of M. pinnata flower. Consequently, to authenticate the results and to establish the antioxidant, antibacterial, an anti-diabetic and anti-inflammatory agent, in vivo studies are made in the molecular level.