One-Pot Au[III]-/Lewis Acid Catalyzed Cycloisomerization of Nitroalkynes and [3 + 3]Cycloaddition with Donor–Acceptor Cyclopropanes

A one-pot protocol for the synthesis of a tricyclic pseudoindoxyl scaffold from 2-nitroalkynylbenzenes, comprising of an Au­(III)-catalyzed nitroalkyne cycloisomerization leading to isatogen and its [3 + 3]-cycloaddition with donor–acceptor cyclopropanes mediated by a suitable Lewis acid, has been d...

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Bibliographic Details
Published in:Organic letters 2019-08, Vol.21 (16), p.6221-6224
Main Authors: Dhote, Pawan S, Ramana, Chepuri V
Format: Article
Language:English
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Summary:A one-pot protocol for the synthesis of a tricyclic pseudoindoxyl scaffold from 2-nitroalkynylbenzenes, comprising of an Au­(III)-catalyzed nitroalkyne cycloisomerization leading to isatogen and its [3 + 3]-cycloaddition with donor–acceptor cyclopropanes mediated by a suitable Lewis acid, has been developed.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.9b02035