The first evidence of an association between a polymorphism in the endocannabinoid-degrading enzyme FAAH (FAAH rs2295633) with attention deficit hyperactivity disorder

Several single nucleotide polymorphisms (SNPs) of the fatty acid amide hydrolase (FAAH), the degrading enzyme of the endocannabinoids, have been shown to be associated with many neuropsychiatric disorders. Here, FAAH rs2295633 was studied in ADHD and case-control healthy children. There was a signif...

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Bibliographic Details
Published in:Genomics (San Diego, Calif.) Calif.), 2020-03, Vol.112 (2), p.1330-1334
Main Authors: Ahmadalipour, Ali, Mehdizadeh Fanid, Leila, Zeinalzadeh, Narges, Alizadeh, Maedeh, Vaezi, Helaleh, Hassanpour Aydinlou, Zahra, Noorazar, Seyed Gholamreza
Format: Article
Language:English
Subjects:
ADHD
Amidohydrolases - genetics
Attention Deficit Disorder with Hyperactivity - genetics
Attention deficit hyperactivity disorder
Child
Endocannabinoids
FAAH gene
Female
Genetic association
Humans
Male
Polymorphism, Single Nucleotide
rs2295633
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Summary:Several single nucleotide polymorphisms (SNPs) of the fatty acid amide hydrolase (FAAH), the degrading enzyme of the endocannabinoids, have been shown to be associated with many neuropsychiatric disorders. Here, FAAH rs2295633 was studied in ADHD and case-control healthy children. There was a significant difference in the allele frequency (P = .04) and genotype distribution (P = .04) of the FAAH rs2295633 between ADHD cases and controls. The ADHD children appeared to have less of TT genotype (OR 0.396, 95% CI 0.178–0.884, p = .024) and T allele (OR 0.658, 95% CI 0.440–0.982, p = .04). To our best knowledge, this is the first statistical significant association between FAAH rs2295633 genotype and ADHD disorder. Larger sample sizes and functional studies are warranted to explore the clinical utility of FAAH genotyping as a possible marker for increased ADHD risk in children. •Multiple risk genes are responsible for the underlying liability to ADHD.•Endocannabinoid system is associated with several psychiatric disorders.•Fatty acid amide hydrolase (FAAH) is a degrading enzyme of the endocannabinoids.•We investigated the relationship between FAAH SNP rs2295633 and ADHD.•We presented a plausible association of polymorphism in FAAH rs2295633 with ADHD.
ISSN:0888-7543
1089-8646
DOI:10.1016/j.ygeno.2019.07.024