Longitudinal change in blood pressure and risk of end-stage renal disease in a community-based cohort in Okinawa

Background The appropriate blood pressure target to prevent end-stage renal disease (ESRD) is controversial. Methods We examined the association between systolic blood pressure (SBP) changes and ESRD incidence in 69,575 participants from the Okinawa general population aged ≥ 20 years who underwent h...

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Bibliographic Details
Published in:Clinical and experimental nephrology 2019-11, Vol.23 (11), p.1280-1287
Main Authors: Usui, Tomoko, Iseki, Chiho, Iseki, Kunitoshi, Kawakami, Koji, Nangaku, Masaomi
Format: Article
Language:English
Subjects:
Adult
Aged
Blood Pressure
Dialysis
End-stage renal disease
Female
Humans
Hypertension - epidemiology
Incidence
Japan - epidemiology
Kidney diseases
Kidney Failure, Chronic - epidemiology
Longitudinal Studies
Male
Medicare
Medicine
Medicine & Public Health
Middle Aged
Nephrology
Original Article
Proportional Hazards Models
Registries
Risk Factors
Systole
Urology
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Summary:Background The appropriate blood pressure target to prevent end-stage renal disease (ESRD) is controversial. Methods We examined the association between systolic blood pressure (SBP) changes and ESRD incidence in 69,575 participants from the Okinawa general population aged ≥ 20 years who underwent health check-ups in 1993 and more than once in 1994–1996. ESRD incidence was identified using dialysis registry until 2011. Cox proportional hazards model was used to estimate hazard ratio (95% confidence interval) with confounding factor adjustment. Results At baseline, 29.9%, 22.1%, 20.6%, and 27.5% of subjects had SBP 
ISSN:1342-1751
1437-7799
DOI:10.1007/s10157-019-01771-0