A Nanobody‐Conjugated DNA Nanoplatform for Targeted Platinum‐Drug Delivery

The targeted delivery of chemotherapeutic drugs is a major challenge in the clinical treatment of cancer. Herein, we constructed a multifunctional DNA nanoplatform as a versatile carrier of the highly potent platinum‐based DNA intercalator, 56MESS. In our rational design, 56MESS was efficiently load...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2019-10, Vol.58 (40), p.14224-14228
Main Authors: Wu, Tiantian, Liu, Jianbing, Liu, Manman, Liu, Shaoli, Zhao, Shuai, Tian, Run, Wei, Dengshuai, Liu, Yangzhong, Zhao, Yao, Xiao, Haihua, Ding, Baoquan
Format: Article
Language:English
Subjects:
Biomarkers
cancer therapy
Deoxyribonucleic acid
DNA
DNA nanotechnology
Drug delivery
Drug delivery systems
Epidermal growth factor
Epidermal growth factor receptors
Gene expression
Growth factors
Nanobodies
nanobody
Platinum
Selectivity
Tetrahedra
Toxicity
Tumors
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Summary:The targeted delivery of chemotherapeutic drugs is a major challenge in the clinical treatment of cancer. Herein, we constructed a multifunctional DNA nanoplatform as a versatile carrier of the highly potent platinum‐based DNA intercalator, 56MESS. In our rational design, 56MESS was efficiently loaded into the double‐bundle DNA tetrahedron through intercalation with the DNA duplex. With the integration of a nanobody that both targets and blocks epidermal growth factor receptor (EGFR), the DNA nanocarriers exhibit excellent selectivity for cells with elevated EGFR expression (a common biomarker related to tumor formation) and combined tumor therapy without obvious systemic toxicity. This DNA‐based platinum‐drug delivery system provides a promising strategy for the treatment of tumors. A double‐bundle DNA tetrahedron‐based nanoplatform integrating a nanobody, which targets and blocks the epidermal growth factor receptor (EGFR), commonly overexpressed on the surface of tumor cells, and a platinum‐based DNA intercalator (56MESS) was constructed for efficient and targeted tumor therapy.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201909345