Human umbilical cord mesenchymal stem cells derived-exosomes in diseases treatment

Exosomes are extracellular vesicles with the size of 40–100 nm in diameter and a density of 1.13–1.19 g/mL, containing proteins, mRNAs, miRNAs, and DNAs. Exosomes change the recipient cells biochemical features through biomolecules delivery and play a role in cellular communication. These vesicles a...

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Bibliographic Details
Published in:Life sciences (1973) 2019-09, Vol.233, p.116733-116733, Article 116733
Main Authors: Yaghoubi, Yoda, Movassaghpour, AliAkbar, Zamani, Majid, Talebi, Mehdi, Mehdizadeh, Amir, Yousefi, Mehdi
Format: Article
Language:English
Subjects:
Biomolecules
Body fluids
Cell interactions
Cellular communication
Clinical application
Diseases
Exosome
Exosomes
Human umbilical cord
Immunogenicity
Medical treatment
Mesenchymal stem cells
Mesenchyme
Regenerative medicine
Stem cells
Umbilical cord
Vesicles
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Summary:Exosomes are extracellular vesicles with the size of 40–100 nm in diameter and a density of 1.13–1.19 g/mL, containing proteins, mRNAs, miRNAs, and DNAs. Exosomes change the recipient cells biochemical features through biomolecules delivery and play a role in cellular communication. These vesicles are produced from body fluids and different cell types like mesenchymal stem cells (MSCs). Evidence suggests that mesenchymal stem cells-derived exosome (MSC-EXO) exhibit functions similar to MSCs with low immunogenicity and no tumorization. MSCs can also be isolated from a variety of sources including human umbilical cord (HUC). Because of the non-invasive collection method, higher proliferation and lower immunogenicity, HUCMSC-EXO has been frequently used in regenerative medicine and various diseases treatment compared to the other MSC-EXO resources. This review aimed to investigate the applications of HUCMSC-EXO in different diseases.
ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2019.116733