Facile synthesis of 1,2-thiobenzonitriles via Cu-catalyzed denitrogenative radical coupling reaction

A Cu-catalyzed synthesis of 1,2-thiobenzonitriles via oxidative C-N cleavage of 3-aminoindazoles followed by radical coupling with thiols is developed. A diverse array of 1,2-thiobenzonitriles were obtained in good yields with wide substrate scope. Notably, this is the first example of denitrogenati...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2019-08, Vol.55 (69), p.10265-10268
Main Authors: Zhou, Yao, Wang, Ya, Lou, Yixian, Song, Qiuling
Format: Article
Language:English
Subjects:
Chemical synthesis
Coupling
Crystallography
Substrates
Thiols
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Summary:A Cu-catalyzed synthesis of 1,2-thiobenzonitriles via oxidative C-N cleavage of 3-aminoindazoles followed by radical coupling with thiols is developed. A diverse array of 1,2-thiobenzonitriles were obtained in good yields with wide substrate scope. Notably, this is the first example of denitrogenative radical coupling with 3-aminoindazoles.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc05099j