Decreased bone mineral density and associated factors in severe haemophilia A patients: A case‐control study

Introduction Haemophilia patients may exhibit lower levels of bone mineral density (BMD) than the general population for a variety of reasons. Aim We aimed to investigate decreased BMD in people with severe adult haemophilia A (PWH) living in eastern Turkey, and to evaluate the related potential ris...

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Bibliographic Details
Published in:Haemophilia : the official journal of the World Federation of Hemophilia 2019-09, Vol.25 (5), p.e315-e321
Main Authors: Ekinci, Omer, Demircioglu, Sinan, Dogan, Ali, Merter, Mustafa, Yildiz, Saliha, Demir, Cengiz
Format: Article
Language:English
Subjects:
Adolescent
Adult
Body mass index
Bone density
Bone Density - genetics
Bone mineral density
Case-Control Studies
Dual energy X-ray absorptiometry
Femur
haemophilia
Hemophilia
Hemophilia A - complications
Hip
Humans
Male
Middle Aged
Multivariate analysis
Osteopenia
Osteoporosis
Osteoporosis - complications
Risk Factors
Spine (lumbar)
Vitamin D
Vitamin deficiency
Young Adult
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Summary:Introduction Haemophilia patients may exhibit lower levels of bone mineral density (BMD) than the general population for a variety of reasons. Aim We aimed to investigate decreased BMD in people with severe adult haemophilia A (PWH) living in eastern Turkey, and to evaluate the related potential risk factors. Methods The study included 41 PWH and 40 healthy volunteers. Dual‐energy x‐ray absorptiometry (DXA) was used to measure the BMD. Blood tests and body mass index (BMI) were recorded. The Functional Independence Score in Hemophilia (FISH) test was used to measure functional ability status. Results There was a significant difference between the PWH and control groups with respect to femoral neck and total hip BMD (in g/cm2), but the difference for lumbar spine was not significant (P = .017, P 
ISSN:1351-8216
1365-2516
DOI:10.1111/hae.13836