Fetal liver stem cell transplantation for liver diseases

Stem cell transplantation exhibited a promising lifesaving therapy for various end-stage liver diseases and could serve as a salvaging bridge until curative methods can be performed. In past decades, mature hepatocytes, liver progenitor cells, mesenchymal stem cells and induced pluripotent stem cell...

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Bibliographic Details
Published in:Regenerative medicine 2019-07, Vol.14 (7), p.703-714
Main Authors: Yasen, Aimaiti, Tuxun, Tuerhongjiang, Apaer, Shadike, Li, Wending, Maimaitinijiati, Yusufukadier, Wang, Hui, Aisan, Meiheriayi, Aji, Tuerganaili, Shao, Yingmei, Hao, Wen
Format: Article
Language:English
Subjects:
Animals
Fetal Stem Cells - transplantation
Gastroenterology
Genetic Diseases, Inborn - genetics
Genetic Diseases, Inborn - metabolism
Genetic Diseases, Inborn - pathology
Genetic Diseases, Inborn - therapy
Genetic Therapy
Humans
Induced Pluripotent Stem Cells - metabolism
Induced Pluripotent Stem Cells - pathology
Induced Pluripotent Stem Cells - transplantation
Injuries
Liver cirrhosis
Liver diseases
Liver Diseases - genetics
Liver Diseases - metabolism
Liver Diseases - pathology
Liver Diseases - therapy
liver regeneration
Mesenchymal Stem Cells - metabolism
Mesenchymal Stem Cells - pathology
setal liver stem cells
Stem Cell Transplantation
Stem cells
Studies
Transplants & implants
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Summary:Stem cell transplantation exhibited a promising lifesaving therapy for various end-stage liver diseases and could serve as a salvaging bridge until curative methods can be performed. In past decades, mature hepatocytes, liver progenitor cells, mesenchymal stem cells and induced pluripotent stem cells have been practiced in above settings. However, long-term survival rates and continuous proliferation ability of these cells are unsatisfactory, whereas, fetal liver stem cells (FLSCs), given their unique superiority, may be the best candidate for stem cell transplantation technique. Recent studies have revealed that FLSCs could be used as an attractive genetic therapy or regenerative treatments for inherited metabolic or other hepatic disorders. In this study, we reviewed current status and advancements of FLSCs-based treatment.
ISSN:1746-0751
1746-076X
DOI:10.2217/rme-2018-0160