Long-term Results of Kidney Transplantation in Patients With Familial Mediterranean Fever and Amyloidosis

• Published in: Transplantation proceedings 2019-09, Vol.51 (7), p.2289-2291
• Main Authors: Sarıtaş, Hazen, Sendogan, Damla Ors, Kumru, Gizem, Sadioglu, Rezzan Eren, Duman, Neval, Erturk, Sehsuvar, Nergisoglu, Gokhan, Tuzuner, Acar, Sengul, Sule, Keven, Kenan
• Format: Article
• Language: English
• Subjects: Adult; Amyloidosis - etiology; Familial Mediterranean Fever - complications; Female; Graft Rejection - epidemiology; Graft Rejection - etiology; Humans; Kidney Failure, Chronic - etiology; Kidney Failure, Chronic - surgery; Kidney Transplantation - adverse effects; Male; Middle Aged; Retrospective Studies; Treatment Outcome; Turkey
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2019.04.074

Amyloid A amyloidosis is most commonly caused by familial Mediterranean fever (FMF) in Turkey. Amyloidosis secondary to FMF is an important cause of end-stage renal failure, and kidney transplantation (KT) in these cases can be complicated, with long-term results oftentimes inferior compared with organ transplant in patients without FMF. The present study aims to show the long-term results of patients with secondary amyloidosis caused by FMF undergoing KT . We enrolled 27 patients with a history of FMF amyloidosis undergoing KT and a control group of 614 patients undergoing KT between 2005 and 2018 at Ankara University Medical School. All data were recorded retrospectively from patients files. Twenty-two patients (81.5%) were treated with triple immunosuppressive therapy consisting of mycophenolate mofetil, tacrolimus, and a steroid; 5 patients (18.5%) were treated with tacrolimus, azathioprine, and prednisolone. Acute cellular rejection was seen in 3 patients (11.1%), and acute cellular- and antibody-mediated rejection occurred in 1 patient (3.7%). During the follow-up period, graft loss due to acute cellular rejection was observed in only 1 patient. One patient was lost to follow-up. •Familial Mediterranean fever (FMF) is the most common hereditary autoinflammatory disease.•Long-term outcomes of patients with FMF-related amyloidosis who have received kidney transplantation (KT) are controversial.•Our study shows that the long-term outcome of KT in patients with FMF amyloidosis is similar to control recipients of KT.