HPV-Related Multiphenotypic Sinonasal Carcinoma: A Unique Case

Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma (HMSC), originally known as HPV-related carcinoma with adenoid cystic carcinoma-like features, is a recently described neoplasm that presents only in the sinonasal tract, displays features of both a surface-derived carcinoma and...

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Bibliographic Details
Published in:International journal of surgical pathology 2019-12, Vol.27 (8), p.888-892
Main Authors: Ching, Daniel, Pirasteh, Shadi, Ly, Chanh
Format: Article
Language:English
Subjects:
Case reports
Head & neck cancer
Histology
Human papillomavirus
Oral cancer
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Summary:Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma (HMSC), originally known as HPV-related carcinoma with adenoid cystic carcinoma-like features, is a recently described neoplasm that presents only in the sinonasal tract, displays features of both a surface-derived carcinoma and a salivary gland carcinoma, and is associated with high-risk HPV, specifically HPV type 33. Majority of the cases display high-grade histologic features, but HMSC paradoxically behaves in a relatively indolent fashion. Distinguishing HMSC from other histologic mimickers is essential as the management and prognosis are significantly different. In this article, we present a unique case of HMSC and review the literature.
ISSN:1066-8969
1940-2465
DOI:10.1177/1066896919866508