Inflammation and dysfunction in human aortic endothelial cells associated with poly‐l‐lactic acid degradation in vitro are alleviated by curcumin

Poly‐l‐lactic acid (PLLA) is widely used in clinic, for example, as biodegradable coronary artery stents. However, inflammatory responses in endothelial cells associated with PLLA degradation are relatively undefined. We previously reported inflammation in human aortic endothelial cells (HAEC) in vi...

Full description

Saved in:
Bibliographic Details
Published in:Journal of biomedical materials research. Part A 2019-12, Vol.107 (12), p.2756-2763
Main Authors: Chen, Dongping, Weng, Linsheng, Chen, Can, Zheng, Jian, Wu, Tim, Zeng, Sufen, Zhang, Suzhen, Xiao, Jianmin
Format: Article
Language:English
Subjects:
Animal models
Aorta
Biodegradability
Biodegradable materials
Biodegradation
Cell adhesion & migration
Cell migration
Cholecystokinin
Coronary artery
Curcumin
Cytokines
Degradation
endothelial cell
Endothelial cells
Enzyme-linked immunosorbent assay
Implants
Inflammation
Lactic acid
PLLA
Polylactic acid
Polymers
Stents
Thromboembolism
Thrombosis
Wound healing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Poly‐l‐lactic acid (PLLA) is widely used in clinic, for example, as biodegradable coronary artery stents. However, inflammatory responses in endothelial cells associated with PLLA degradation are relatively undefined. We previously reported inflammation in human aortic endothelial cells (HAEC) in vitro and in vivo. Here, we further assessed inflammatory injury, including cell migration, cell function, and inflammatory cytokines expressed in HAEC treated with PLLA and curcumin by CCK‐8, wound healing assay, ELISA, and Western blot. Significant inhibition of cell migration, remarkable dysfunction, and inflammatory responses were found in HAEC treated with PLLA degradation extract, and these effects were alleviated by Cur treatment. These findings indicated that cautious evaluation of biodegradable polymers should be performed, and Cur represents a promising anti‐inflammatory agent for alleviating endothelial dysfunction and inflammation caused by PLLA degradation. In addition, Cur should be further studied experimentally in in vivo experiments on animal models as a potential therapeutic to reduce thrombosis of biodegradable polymer stents.
ISSN:1549-3296
1552-4965
DOI:10.1002/jbm.a.36778