Preoperative change of modified Glasgow prognostic score after stenting predicts the long-term outcomes of obstructive colorectal cancer

Purpose Inflammation-based markers predict the long-term outcomes of various malignancies. We investigated the relationship between the modified Glasgow prognostic score (mGPS) and the long-term outcomes of obstructive colorectal cancer in patients who underwent self-expandable metallic colonic sten...

Full description

Saved in:
Bibliographic Details
Published in:Surgery today (Tokyo, Japan) Japan), 2020-03, Vol.50 (3), p.232-239
Main Authors: Sato, Ryuichiro, Oikawa, Masaya, Kakita, Tetsuya, Okada, Takaho, Abe, Tomoya, Yazawa, Takashi, Tsuchiya, Haruyuki, Akazawa, Naoya, Sato, Masaki, Ohira, Tetsuya, Harada, Yoshihiro, Okano, Haruka, Ito, Kei, Ohuchi, Noriaki, Tsuchiya, Takashi
Format: Article
Language:English
Subjects:
Medicine
Medicine & Public Health
Original Article
Surgery
Surgical Oncology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose Inflammation-based markers predict the long-term outcomes of various malignancies. We investigated the relationship between the modified Glasgow prognostic score (mGPS) and the long-term outcomes of obstructive colorectal cancer in patients who underwent self-expandable metallic colonic stent placement and subsequently received curative surgery. Methods We retrospectively analyzed 63 consecutive patients with pathological stage II and III obstructive colorectal cancer from 2013 to 2018. The mGPS was calculated before stenting and surgery, and the difference of the scores was defined as the d-mGPS. Results All d-mGPS = 2 patients were > 70 years of age ( p  = 0.01). Postoperative complications were more common in the preoperative mGPS = 2 group ( p  = 0.02). The postoperative hospital stay was significantly longer in the mGPS = 2 group ( p  = 0.007). Multivariate analyses revealed that d-mGPS was an independent prognostic factor for overall survival (OS) (hazard ratio [HR] = 9.18, p  = 0.004) and cancer-specific survival (HR = 9.98, p  = 0.01). Preoperative mGPS = 2 was significantly associated with poor OS (HR = 5.53, p  = 0.04). Conclusion The results indicated that mGPS might serve as a valuable indicator of the immunonutritional status of preoperative patients, and a preoperative change of the status might affect the long-term outcomes of patients with obstructive colorectal cancer.
ISSN:0941-1291
1436-2813
DOI:10.1007/s00595-019-01862-1