Early pregnancy biochemical markers of placentation for screening of gestational diabetes mellitus (GDM)

For the effective management and screening of patients with diabetes, lipid profile has been a useful mean. Here, we hypothesized that biochemical analyses of blood serum in pregnant women with GDM will develop an insight on the pathogenesis of the disease and possibly uncover new biomarkers. In ord...

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Published in:Diabetes & metabolic syndrome clinical research & reviews 2019-07, Vol.13 (4), p.2353-2356
Main Authors: Alyas, Sobia, Roohi, Nabila, Ashraf, Samina, Ilyas, Sadaf, Ilyas, Azhar
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biomarkers - blood
Blood Glucose - analysis
Blood serum
C-Reactive Protein - analysis
Diabetes, Gestational - blood
Diabetes, Gestational - diagnosis
Diabetes, Gestational - epidemiology
Early Diagnosis
Female
Follow-Up Studies
Gestational Age
Gestational diabetes mellitus (GDM)
Glycated Hemoglobin A - analysis
High-sensitivity C-Reactive protein (hs-CRP)
Humans
Lipid profile
Lipids - blood
Low density lipoproteins (LDL)
Mass Screening - methods
Pakistan - epidemiology
Placentation
Pregnancy
Prognosis
Risk Factors
Triglycerides - blood
Young Adult
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Summary:For the effective management and screening of patients with diabetes, lipid profile has been a useful mean. Here, we hypothesized that biochemical analyses of blood serum in pregnant women with GDM will develop an insight on the pathogenesis of the disease and possibly uncover new biomarkers. In order to test our hypothesis, antenatal pregnant women (n = 300) were selected for blood samples including 176 with positive clinical/family history and 124 with negative clinical/family history of GDM during the early second trimester (14–18 weeks of gestation). All the subjects were followed up to the early third trimester (24–28 weeks of gestation) for second sampling until the onset of GDM. Lipid profile data shows that mean values of triglycerides, total cholesterol, low density lipids and very low density lipids were significantly higher (p 
ISSN:1871-4021
1878-0334
DOI:10.1016/j.dsx.2019.06.006