Bmi1 restricts the adipogenic differentiation of bone marrow stromal cells to maintain the integrity of the hematopoietic stem cell niche

Highlights•Bmi1 loss promotes the adipogenic differentiation of bone marrow stromal cells. •Bmi1 restricts the stress-induced adipogenic differentiation of stromal cells. •Bmi1 maintains the integrity of the hematopoietic stem cell niche.

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Bibliographic Details
Published in:Experimental hematology 2019-08, Vol.76, p.24-37
Main Authors: Kato, Yuko, Hou, Li-Bo, Miyagi, Satoru, Nitta, Eriko, Aoyama, Kazumasa, Shinoda, Daisuke, Yamazaki, Satoshi, Kuribayashi, Wakako, Isshiki, Yusuke, Koide, Shuhei, Si, Sha, Saraya, Atsunori, Matsuzaki, Yumi, van Lohuizen, Maarten, Iwama, Atsushi
Format: Article
Language:English
Subjects:
Adipogenesis - physiology
Advanced Basic Science
Animals
Bone Marrow - pathology
Bone Marrow - physiology
Cell Line
Cell Self Renewal
Gene Expression Profiling
Gene Expression Regulation, Developmental
Hematology, Oncology, and Palliative Medicine
Hematopoietic Stem Cells - cytology
Mice
Mice, Congenic
Mice, Inbred C57BL
Mice, Knockout
Polycomb Repressive Complex 1 - deficiency
Polycomb Repressive Complex 1 - physiology
Proto-Oncogene Proteins - deficiency
Proto-Oncogene Proteins - physiology
Receptors, Leptin - analysis
Regeneration
Stem Cell Niche
Stromal Cells - chemistry
Stromal Cells - pathology
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Description
Summary:Highlights•Bmi1 loss promotes the adipogenic differentiation of bone marrow stromal cells. •Bmi1 restricts the stress-induced adipogenic differentiation of stromal cells. •Bmi1 maintains the integrity of the hematopoietic stem cell niche.
ISSN:0301-472X
1873-2399
DOI:10.1016/j.exphem.2019.07.006