ESWL for large pancreatic calculi: Report of over 5000 patients

• Published in: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2019-10, Vol.19 (7), p.916-921
• Main Authors: Tandan, Manu, Nageshwar Reddy, D., Talukdar, Rupjyoti, Vinod, K., Kiran, S.V.V.S., Santosh, D., Gupta, Rajesh, Ramchandani, Mohan, Lakhtakia, Sundeep, Rakesh, K., Manohar Reddy, P., Basha, Jahangeer, Nabi, Zaheer, Jagtap, Nitin, Rao, G.V.
• Format: Article
• Language: English
• Subjects: Adult; Alcohol; Analgesics; Calcification (ectopic); Calculi - therapy; Chronic pancreatitis; Complications; Cysts; Endoscopy; ERCP; ESWL; Female; Humans; Hypertension; Large pancreatic ductal calculi; Lithotripsy; Male; Middle Aged; Outcomes; Pain; Pancreas; Pancreatic Diseases - therapy; Patients; Retrospective Studies; Ultrasonic imaging; Young Adult
• ISSN: 1424-3903; 1424-3911
• DOI: 10.1016/j.pan.2019.08.001

The primary aim of this study was to evaluate efficacy, safety and short-term pain relief after ESWL for large pancreatic calculi in over 5000 patients at a single center. This is a retrospective analysis of prospectively collected data. Patients with painful calculi >5 mm, located in the head, neck and body region in the MPD, who were not amenable for extraction by the standard procedure of endoscopic pancreatic sphincterotomy were subjected to ESWL using a third generation dual focus lithotripter. Patients were followed up at 6 months for outcome evaluation. A total of 5124 patients (66% males) were subjected to ESWL. Majority of stones (79.2%) were radiopaque. Single calculi were seen in 3851 (75.1%).The majority of stones were located in head region of MPD in 2824 (55.1%) patients. 4386 (85.5%) patients required 3 or less sessions for fragmentation and complete stone clearance was achieved in 3722 (72.6%). EPS was performed in 5022 (98%) while PD stenting was required in 3536 (69%) patients. Of the 4280 patients followed up for 6 months, 3529 (82.6%) patients were pain free. Another 512 (11.9%) patients had significant reduction in VAS score. In 229 (5.3%) there was no decrease in pain intensity. Minor and self-limiting complications were reported in 1153 (22.5%). Our study confirms the safety and efficacy and short-term pain relief of ESWL for large calculi in the MPD. In properly selected patients, this should be offered as the first line of therapy for all large MPD calculi not amenable to the standard techniques of stone extraction.