Results of a prospective clinical trial JN‐L‐10 using image‐defined risk factors to inform surgical decisions for children with low‐risk neuroblastoma disease: A report from the Japan Children's Cancer Group Neuroblastoma Committee

Background The present study sought to reduce the incidence of treatment complications of low‐risk neuroblastoma by using image‐defined risk factors (IDRFs) to inform the timing of surgical resection. Procedures Eligible patients included children (

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Bibliographic Details
Published in:Pediatric blood & cancer 2019-11, Vol.66 (11), p.e27914-n/a
Main Authors: Iehara, Tomoko, Yoneda, Akihiro, Yokota, Isao, Takahashi, Hideto, Teramukai, Satoshi, Kamijyo, Takehiko, Nakazawa, Atsuko, Takimoto, Tetsuya, Kikuta, Atsushi, Yagyu, Shigeki, Ikeda, Hitoshi, Nakagawara, Akira, Tajiri, Tatsuro
Format: Article
Language:English
Subjects:
Adolescent
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Ascites
Atrophy
Carboplatin
Carboplatin - administration & dosage
Carboplatin - adverse effects
Chemotherapy
Chemotherapy-Induced Febrile Neutropenia - etiology
Child
Child, Preschool
Children
Clinical Decision-Making
Clinical trials
Combined Modality Therapy
Complications
Cyclophosphamide
Cyclophosphamide - administration & dosage
Cyclophosphamide - adverse effects
Decision making
Doxorubicin - administration & dosage
Doxorubicin - adverse effects
Doxorubicin - analogs & derivatives
Female
Ganglioneuroblastoma - diagnostic imaging
Ganglioneuroblastoma - drug therapy
Ganglioneuroblastoma - surgery
Health risks
Hematology
Humans
IDRFs
Incidence
Infant
Infant, Newborn
Infants
Japan
Kaplan-Meier Estimate
low‐risk
Magnetic Resonance Imaging
Male
Medical prognosis
Medical treatment
Neuroblastoma
Neuroblastoma - diagnostic imaging
Neuroblastoma - drug therapy
Neuroblastoma - surgery
Neutropenia
Oncology
Patients
Pediatrics
Pleural effusion
Pleural Effusion - etiology
Postoperative Complications - etiology
Progression-Free Survival
Prospective Studies
Risk Factors
Surgery
Survival
Tomography, Emission-Computed, Single-Photon
Tomography, X-Ray Computed
Toxicity
Vascular Diseases - etiology
Vincristine
Vincristine - administration & dosage
Vincristine - adverse effects
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Description
Summary:Background The present study sought to reduce the incidence of treatment complications of low‐risk neuroblastoma by using image‐defined risk factors (IDRFs) to inform the timing of surgical resection. Procedures Eligible patients included children (
ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.27914