LncRNA HEIH regulates cell proliferation and apoptosis through miR-4458/SOCS1 axis in triple-negative breast cancer

Hepatocellular carcinoma up-regulated EZH2-associated long non-coding RNA (HEIH) is a newly discovered lncRNA and has been suggested to be dysregulated in human cancers. However, the role of HEIH in triple-negative breast cancer (TNBC) was still unknown. Thus, the aim of our study was to investigate...

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Bibliographic Details
Published in:Human cell : official journal of Human Cell Research Society 2019-10, Vol.32 (4), p.522-528
Main Authors: Li, Peng, Zhou, Bo, Lv, Yuetao, Qian, Qian
Format: Article
Language:English
Subjects:
Apoptosis
Binding Sites
Biomedical and Life Sciences
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Cell Biology
Cell growth
Cell Line, Tumor
Cell proliferation
Cell Proliferation - genetics
Down-Regulation
Enhancer of Zeste Homolog 2 Protein - genetics
Epithelial cells
Female
Gene Expression
Gynecology
Hepatocellular carcinoma
Humans
Life Sciences
Mammary gland
MicroRNAs - genetics
MicroRNAs - metabolism
Non-coding RNA
Oncology
Reproductive Medicine
Research Article
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
Stem Cells
Suppressor of Cytokine Signaling 1 Protein - genetics
Suppressor of Cytokine Signaling 1 Protein - metabolism
Surgery
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Summary:Hepatocellular carcinoma up-regulated EZH2-associated long non-coding RNA (HEIH) is a newly discovered lncRNA and has been suggested to be dysregulated in human cancers. However, the role of HEIH in triple-negative breast cancer (TNBC) was still unknown. Thus, the aim of our study was to investigate the clinical significance and biological function of HEIH in TNBC. In our study, we found that HEIH was overexpressed in TNBC tissues and cell lines compared with adjacent normal mammary tissues and normal mammary epithelial cell line, respectively. In addition, we conducted bioinformatic analysis, and found that HEIH harbors a potential miR-4458-binding site. Furthermore, we observed that HEIH and miR-4458 had a high correlation score in TNBC tissues, and HEIH directly binds to miR-4458, and negatively regulates miR-4458 expression in TNBC cells. The in vitro cell proliferation and apoptosis assays suggested down-regulation of HEIH inhibited TNBC cell proliferation and promoted apoptosis through regulating miR-4458/SOCS1 axis. Finally, we found that TNBC patients with tumor size ≥ 5 cm or advanced clinical stage had higher levels of HEIH expression than patients with tumor size
ISSN:1749-0774
0914-7470
1749-0774
DOI:10.1007/s13577-019-00273-1