Phytochemical, anti-inflammatory and anti-trypanosomal properties of Anthocleista vogelii Planch (Loganiaceae) stem bark

Anthocleista vogelii Planch (Loganiaceae) is used in African Traditional Medicine for the treatment of pain and inflammatory disorders as well as sleeping sickness. To determine the in vivo anti-inflammatory and in vitro anti-trypanosomal activities of the extracts of A. vogelii stem bark and identi...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2019-06, Vol.238 (NA), p.111851-111851, Article 111851
Main Authors: Eze, Fabian Ifeanyi, Siwe Noundou, Xavier, Osadebe, Patience O., Krause, Rui W.M.
Format: Article
Language:English
Subjects:
Animals
Anthocleista vogelii
Anti-inflammatory
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
Anti-trypanosomal
Cell Survival - drug effects
Cytotoxicity
Edema - drug therapy
Female
HeLa Cells
Humans
Lethal Dose 50
Loganiaceae
Male
Mice
Phytochemical analysis
Phytochemicals - analysis
Phytochemicals - pharmacology
Phytochemicals - therapeutic use
Plant Bark
Plant Stems
Rats, Wistar
Trypanocidal Agents - chemistry
Trypanocidal Agents - pharmacology
Trypanocidal Agents - therapeutic use
Trypanosoma brucei brucei - drug effects
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Summary:Anthocleista vogelii Planch (Loganiaceae) is used in African Traditional Medicine for the treatment of pain and inflammatory disorders as well as sleeping sickness. To determine the in vivo anti-inflammatory and in vitro anti-trypanosomal activities of the extracts of A. vogelii stem bark and identify the phytochemical classes of the fractions responsible for the activities. The in vivo anti-inflammatory activity of the extracts was evaluated using the egg albumin-induced rat paw oedema model while the in vitro anti-trypanosomal activity was assessed on Trypanosoma brucei brucei. The in vitro cytotoxicity was assessed on HeLa (human cervix adenocarcinoma) cell line. The methanolic extract of A. vogelii stem bark, with 11.2% yield, gave LD50 > 5000 mg/kg. The n-hexane fraction of the extract contains steroids, terpenes and fatty acids and yielded non-cytotoxic terpenoidal column fraction with anti-trypanosomal IC50 of 3.0 μg/mL. The ethylacetate fraction at 100 mg/kg dose significantly (p 
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2019.111851