Expression patterns of aquaporin 1 in vascular tumours

Background Aquaporins (AQPs) are a family of water channels expressed in various body tissues. Beyond osmotic balance, AQPs have recently been confirmed to be involved in processes related to cancer (tumour proliferation, angiogenesis, etc. ). Objectives To analyse the presence of these proteins in...

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Bibliographic Details
Published in:EJD. European journal of dermatology 2019-08, Vol.29 (4), p.366-370
Main Authors: Narváez-Moreno, Basilio, Sendín-Martín, Mercedes, Jiménez-Thomas, Guillermo, Sánchez-Silva, Rocío, Syárez-Luna, Nela, Echevarría, Miriam, Bernabeu-Wittel, José
Format: Article
Language:English
Subjects:
Adult
Aquaporin 1 - genetics
Biomarkers, Tumor - genetics
Biopsy, Needle
Cohort Studies
Confidence Intervals
Dermatology
Diagnosis, Differential
Female
Gene Expression Regulation, Neoplastic
Hemangioma - genetics
Hemangioma - pathology
Hemangiosarcoma - genetics
Hemangiosarcoma - pathology
Humans
Immunohistochemistry
Investigative Report
Male
Medicine
Medicine & Public Health
Sarcoma, Kaposi - genetics
Sarcoma, Kaposi - pathology
Vascular Neoplasms - genetics
Vascular Neoplasms - pathology
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Summary:Background Aquaporins (AQPs) are a family of water channels expressed in various body tissues. Beyond osmotic balance, AQPs have recently been confirmed to be involved in processes related to cancer (tumour proliferation, angiogenesis, etc. ). Objectives To analyse the presence of these proteins in the endothelium of several vascular tumours, both benign and malignant, in order to establish whether AQPs may be used as a marker or future therapeutic target. Materials and Methods We studied AQP1 expression in 39 patients with vascular tumours, classified into six groups according to ISSVA classification: haemangiomas, benign vascular tumours different from infantile haemangiomas, angiosarcomas, classic Kaposi’s sarcoma (KS), and epidemic KS. Results AQP1 expression was present in 28 of 39 patients, representing 92.9% benign lesions, whereas no expression was found in 72% of malignant lesions. AQP1 expression was associated with benign lesions with an OR of 34.5 (95% CI: 5-250); p
ISSN:1167-1122
1952-4013
DOI:10.1684/ejd.2019.3602