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Benign acute viral myositis in African migrants: A clinical, serological, and pathological study
Background Several viruses have been described as causes of acquired inflammatory myopathies; however, the mechanisms by which they cause muscle disease are still unclear. The aim of this study was to describe the laboratory features of benign acute myositis in a small case series. Methods A detaile...
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| Published in: | Muscle & nerve 2019-11, Vol.60 (5), p.586-590 |
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| container_issue | 5 |
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| container_title | Muscle & nerve |
| container_volume | 60 |
| creator | Pancheri, Elia Lanzafame, Massimiliano Zamò, Alberto Angheben, Andrea Sartoris, Silvia Zorzi, Antonella Boaretti, Marzia Signoretto, Caterina Guglielmi, Valeria Ferrari, Sergio Tonin, Paola Vattemi, Gaetano |
| description | Background
Several viruses have been described as causes of acquired inflammatory myopathies; however, the mechanisms by which they cause muscle disease are still unclear. The aim of this study was to describe the laboratory features of benign acute myositis in a small case series.
Methods
A detailed pathological and serological analysis was performed in five African migrants who developed an acute viral myositis complicated by rhabdomyolysis.
Results
Muscle biopsies clearly documented an inflammatory myopathy with histological features similar to polymyositis including CD8+ T cells surrounding and invading nonnecrotic muscle fibers, CD68+ macrophages and major histocompatibility complex class I antigen upregulation. In addition, positivity for myositis‐specific antibodies (MSA), in particular anti‐aminoacyl tRNA synthetases, was found in the serum of two patients.
Conclusions
Our study demonstrated that T‐cell mediated injury occurs in muscle of patients with acute viral myositis, and that MSA may be present in the serum of these patients. |
| doi_str_mv | 10.1002/mus.26679 |
| format | article |
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Several viruses have been described as causes of acquired inflammatory myopathies; however, the mechanisms by which they cause muscle disease are still unclear. The aim of this study was to describe the laboratory features of benign acute myositis in a small case series.
Methods
A detailed pathological and serological analysis was performed in five African migrants who developed an acute viral myositis complicated by rhabdomyolysis.
Results
Muscle biopsies clearly documented an inflammatory myopathy with histological features similar to polymyositis including CD8+ T cells surrounding and invading nonnecrotic muscle fibers, CD68+ macrophages and major histocompatibility complex class I antigen upregulation. In addition, positivity for myositis‐specific antibodies (MSA), in particular anti‐aminoacyl tRNA synthetases, was found in the serum of two patients.
Conclusions
Our study demonstrated that T‐cell mediated injury occurs in muscle of patients with acute viral myositis, and that MSA may be present in the serum of these patients.</description><identifier>ISSN: 0148-639X</identifier><identifier>EISSN: 1097-4598</identifier><identifier>DOI: 10.1002/mus.26679</identifier><identifier>PMID: 31443116</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Adolescent ; Amino Acyl-tRNA Synthetases - immunology ; Antibodies ; Antibodies, Viral - immunology ; Antigens ; Autoantibodies - immunology ; Cameroon - ethnology ; CD8 antigen ; CD8-Positive T-Lymphocytes - immunology ; Cote d'Ivoire - ethnology ; Coxsackie virus ; Creatine Kinase - blood ; Emigrants and Immigrants ; Ghana - ethnology ; Histocompatibility Antigens Class I - immunology ; Humans ; Immunoglobulin G - immunology ; Immunoglobulin M - immunology ; Inflammation ; Inflammatory diseases ; inflammatory myopathies ; Italy ; Lymphocytes ; Lymphocytes T ; Macrophages ; Macrophages - immunology ; Major histocompatibility complex ; Male ; Migrants ; Muscles ; Musculoskeletal diseases ; Myopathy ; Myositis ; Myositis - complications ; Myositis - immunology ; Myositis - pathology ; Myositis - physiopathology ; myositis‐specific antibodies ; Nigeria - ethnology ; Polymyositis ; Rhabdomyolysis ; Rhabdomyolysis - blood ; Rhabdomyolysis - etiology ; Serology ; Signal Recognition Particle - immunology ; tRNA ; viral myositis ; Virus Diseases - complications ; Virus Diseases - immunology ; Virus Diseases - pathology ; Viruses</subject><ispartof>Muscle & nerve, 2019-11, Vol.60 (5), p.586-590</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3539-de82a8cc58aba818e847e56b3e79472f8166e2457f13e64d272d5b5e7003b523</citedby><cites>FETCH-LOGICAL-c3539-de82a8cc58aba818e847e56b3e79472f8166e2457f13e64d272d5b5e7003b523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31443116$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pancheri, Elia</creatorcontrib><creatorcontrib>Lanzafame, Massimiliano</creatorcontrib><creatorcontrib>Zamò, Alberto</creatorcontrib><creatorcontrib>Angheben, Andrea</creatorcontrib><creatorcontrib>Sartoris, Silvia</creatorcontrib><creatorcontrib>Zorzi, Antonella</creatorcontrib><creatorcontrib>Boaretti, Marzia</creatorcontrib><creatorcontrib>Signoretto, Caterina</creatorcontrib><creatorcontrib>Guglielmi, Valeria</creatorcontrib><creatorcontrib>Ferrari, Sergio</creatorcontrib><creatorcontrib>Tonin, Paola</creatorcontrib><creatorcontrib>Vattemi, Gaetano</creatorcontrib><title>Benign acute viral myositis in African migrants: A clinical, serological, and pathological study</title><title>Muscle & nerve</title><addtitle>Muscle Nerve</addtitle><description>Background
Several viruses have been described as causes of acquired inflammatory myopathies; however, the mechanisms by which they cause muscle disease are still unclear. The aim of this study was to describe the laboratory features of benign acute myositis in a small case series.
Methods
A detailed pathological and serological analysis was performed in five African migrants who developed an acute viral myositis complicated by rhabdomyolysis.
Results
Muscle biopsies clearly documented an inflammatory myopathy with histological features similar to polymyositis including CD8+ T cells surrounding and invading nonnecrotic muscle fibers, CD68+ macrophages and major histocompatibility complex class I antigen upregulation. In addition, positivity for myositis‐specific antibodies (MSA), in particular anti‐aminoacyl tRNA synthetases, was found in the serum of two patients.
Conclusions
Our study demonstrated that T‐cell mediated injury occurs in muscle of patients with acute viral myositis, and that MSA may be present in the serum of these patients.</description><subject>Adolescent</subject><subject>Amino Acyl-tRNA Synthetases - immunology</subject><subject>Antibodies</subject><subject>Antibodies, Viral - immunology</subject><subject>Antigens</subject><subject>Autoantibodies - immunology</subject><subject>Cameroon - ethnology</subject><subject>CD8 antigen</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>Cote d'Ivoire - ethnology</subject><subject>Coxsackie virus</subject><subject>Creatine Kinase - blood</subject><subject>Emigrants and Immigrants</subject><subject>Ghana - ethnology</subject><subject>Histocompatibility Antigens Class I - immunology</subject><subject>Humans</subject><subject>Immunoglobulin G - immunology</subject><subject>Immunoglobulin M - immunology</subject><subject>Inflammation</subject><subject>Inflammatory diseases</subject><subject>inflammatory myopathies</subject><subject>Italy</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Macrophages</subject><subject>Macrophages - immunology</subject><subject>Major histocompatibility complex</subject><subject>Male</subject><subject>Migrants</subject><subject>Muscles</subject><subject>Musculoskeletal diseases</subject><subject>Myopathy</subject><subject>Myositis</subject><subject>Myositis - complications</subject><subject>Myositis - immunology</subject><subject>Myositis - pathology</subject><subject>Myositis - physiopathology</subject><subject>myositis‐specific antibodies</subject><subject>Nigeria - ethnology</subject><subject>Polymyositis</subject><subject>Rhabdomyolysis</subject><subject>Rhabdomyolysis - blood</subject><subject>Rhabdomyolysis - etiology</subject><subject>Serology</subject><subject>Signal Recognition Particle - immunology</subject><subject>tRNA</subject><subject>viral myositis</subject><subject>Virus Diseases - complications</subject><subject>Virus Diseases - immunology</subject><subject>Virus Diseases - pathology</subject><subject>Viruses</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kEtLxDAUhYMoOj4W_gEJuFGwmndSd6P4AsWFCu5q2t6OkTYdk1aZf2-HqgvB1eUcPj4uB6FdSo4pIeyk6eMxU0qnK2hCSaoTIVOziiaECpMonj5voM0Y3wgh1Ci9jjY4FYJTqibo5Qy8m3lsi74D_OGCrXGzaKPrXMTO42kVXGE9btwsWN_FUzzFRe38UNZHOEJo63Y2ButLPLfd60-DY9eXi220Vtk6ws733UKPlxeP59fJ7f3Vzfn0Nim45GlSgmHWFIU0NreGGjBCg1Q5B50KzSpDlQImpK4oByVKplkpcwmaEJ5LxrfQwaidh_a9h9hljYsF1LX10PYxY8xwSqQidED3_6BvbR_88FzGhDJKKZLygTocqSK0MQaosnlwjQ2LjJJsuXrWLLXL1Qd279vY5w2Uv-TPzANwMgKfrobF_6bs7ulhVH4BwQ-LEA</recordid><startdate>201911</startdate><enddate>201911</enddate><creator>Pancheri, Elia</creator><creator>Lanzafame, Massimiliano</creator><creator>Zamò, Alberto</creator><creator>Angheben, Andrea</creator><creator>Sartoris, Silvia</creator><creator>Zorzi, Antonella</creator><creator>Boaretti, Marzia</creator><creator>Signoretto, Caterina</creator><creator>Guglielmi, Valeria</creator><creator>Ferrari, Sergio</creator><creator>Tonin, Paola</creator><creator>Vattemi, Gaetano</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TS</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201911</creationdate><title>Benign acute viral myositis in African migrants: A clinical, serological, and pathological study</title><author>Pancheri, Elia ; Lanzafame, Massimiliano ; Zamò, Alberto ; Angheben, Andrea ; Sartoris, Silvia ; Zorzi, Antonella ; Boaretti, Marzia ; Signoretto, Caterina ; Guglielmi, Valeria ; Ferrari, Sergio ; Tonin, Paola ; Vattemi, Gaetano</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3539-de82a8cc58aba818e847e56b3e79472f8166e2457f13e64d272d5b5e7003b523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Amino Acyl-tRNA Synthetases - immunology</topic><topic>Antibodies</topic><topic>Antibodies, Viral - immunology</topic><topic>Antigens</topic><topic>Autoantibodies - immunology</topic><topic>Cameroon - ethnology</topic><topic>CD8 antigen</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>Cote d'Ivoire - ethnology</topic><topic>Coxsackie virus</topic><topic>Creatine Kinase - blood</topic><topic>Emigrants and Immigrants</topic><topic>Ghana - ethnology</topic><topic>Histocompatibility Antigens Class I - immunology</topic><topic>Humans</topic><topic>Immunoglobulin G - immunology</topic><topic>Immunoglobulin M - immunology</topic><topic>Inflammation</topic><topic>Inflammatory diseases</topic><topic>inflammatory myopathies</topic><topic>Italy</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Macrophages</topic><topic>Macrophages - immunology</topic><topic>Major histocompatibility complex</topic><topic>Male</topic><topic>Migrants</topic><topic>Muscles</topic><topic>Musculoskeletal diseases</topic><topic>Myopathy</topic><topic>Myositis</topic><topic>Myositis - complications</topic><topic>Myositis - immunology</topic><topic>Myositis - pathology</topic><topic>Myositis - physiopathology</topic><topic>myositis‐specific antibodies</topic><topic>Nigeria - ethnology</topic><topic>Polymyositis</topic><topic>Rhabdomyolysis</topic><topic>Rhabdomyolysis - blood</topic><topic>Rhabdomyolysis - etiology</topic><topic>Serology</topic><topic>Signal Recognition Particle - immunology</topic><topic>tRNA</topic><topic>viral myositis</topic><topic>Virus Diseases - complications</topic><topic>Virus Diseases - immunology</topic><topic>Virus Diseases - pathology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pancheri, Elia</creatorcontrib><creatorcontrib>Lanzafame, Massimiliano</creatorcontrib><creatorcontrib>Zamò, Alberto</creatorcontrib><creatorcontrib>Angheben, Andrea</creatorcontrib><creatorcontrib>Sartoris, Silvia</creatorcontrib><creatorcontrib>Zorzi, Antonella</creatorcontrib><creatorcontrib>Boaretti, Marzia</creatorcontrib><creatorcontrib>Signoretto, Caterina</creatorcontrib><creatorcontrib>Guglielmi, Valeria</creatorcontrib><creatorcontrib>Ferrari, Sergio</creatorcontrib><creatorcontrib>Tonin, Paola</creatorcontrib><creatorcontrib>Vattemi, Gaetano</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Muscle & nerve</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pancheri, Elia</au><au>Lanzafame, Massimiliano</au><au>Zamò, Alberto</au><au>Angheben, Andrea</au><au>Sartoris, Silvia</au><au>Zorzi, Antonella</au><au>Boaretti, Marzia</au><au>Signoretto, Caterina</au><au>Guglielmi, Valeria</au><au>Ferrari, Sergio</au><au>Tonin, Paola</au><au>Vattemi, Gaetano</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Benign acute viral myositis in African migrants: A clinical, serological, and pathological study</atitle><jtitle>Muscle & nerve</jtitle><addtitle>Muscle Nerve</addtitle><date>2019-11</date><risdate>2019</risdate><volume>60</volume><issue>5</issue><spage>586</spage><epage>590</epage><pages>586-590</pages><issn>0148-639X</issn><eissn>1097-4598</eissn><abstract>Background
Several viruses have been described as causes of acquired inflammatory myopathies; however, the mechanisms by which they cause muscle disease are still unclear. The aim of this study was to describe the laboratory features of benign acute myositis in a small case series.
Methods
A detailed pathological and serological analysis was performed in five African migrants who developed an acute viral myositis complicated by rhabdomyolysis.
Results
Muscle biopsies clearly documented an inflammatory myopathy with histological features similar to polymyositis including CD8+ T cells surrounding and invading nonnecrotic muscle fibers, CD68+ macrophages and major histocompatibility complex class I antigen upregulation. In addition, positivity for myositis‐specific antibodies (MSA), in particular anti‐aminoacyl tRNA synthetases, was found in the serum of two patients.
Conclusions
Our study demonstrated that T‐cell mediated injury occurs in muscle of patients with acute viral myositis, and that MSA may be present in the serum of these patients.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>31443116</pmid><doi>10.1002/mus.26679</doi><tpages>5</tpages></addata></record> |
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| ispartof | Muscle & nerve, 2019-11, Vol.60 (5), p.586-590 |
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| subjects | Adolescent Amino Acyl-tRNA Synthetases - immunology Antibodies Antibodies, Viral - immunology Antigens Autoantibodies - immunology Cameroon - ethnology CD8 antigen CD8-Positive T-Lymphocytes - immunology Cote d'Ivoire - ethnology Coxsackie virus Creatine Kinase - blood Emigrants and Immigrants Ghana - ethnology Histocompatibility Antigens Class I - immunology Humans Immunoglobulin G - immunology Immunoglobulin M - immunology Inflammation Inflammatory diseases inflammatory myopathies Italy Lymphocytes Lymphocytes T Macrophages Macrophages - immunology Major histocompatibility complex Male Migrants Muscles Musculoskeletal diseases Myopathy Myositis Myositis - complications Myositis - immunology Myositis - pathology Myositis - physiopathology myositis‐specific antibodies Nigeria - ethnology Polymyositis Rhabdomyolysis Rhabdomyolysis - blood Rhabdomyolysis - etiology Serology Signal Recognition Particle - immunology tRNA viral myositis Virus Diseases - complications Virus Diseases - immunology Virus Diseases - pathology Viruses |
| title | Benign acute viral myositis in African migrants: A clinical, serological, and pathological study |
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