Leishmania amazonensis inorganic phosphate transporter system is increased in the proliferative forms

[Display omitted] •Leishmania amazonesis has a high affinity transport system.•Pi influx is energized for an proton gradient.•Promastigote form has a high Pi influx capacity compared with another forms. Here we characterize a high-affinity Pi transport system energized by a H+ gradient in Leishmania...

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Bibliographic Details
Published in:Molecular and biochemical parasitology 2019-10, Vol.233, p.111212-111212, Article 111212
Main Authors: Carvalho-Kelly, Luiz Fernando, Gomes-Vieira, André Luiz, Paes-Vieira, Lisvane, da Silva, Amanda Durval Zeferino, Meyer-Fernandes, José Roberto
Format: Article
Language:English
Subjects:
Cell
Cell proliferation
differentiation
Leishmania amazonensis
Phosphate transport
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Summary:[Display omitted] •Leishmania amazonesis has a high affinity transport system.•Pi influx is energized for an proton gradient.•Promastigote form has a high Pi influx capacity compared with another forms. Here we characterize a high-affinity Pi transport system energized by a H+ gradient in Leishmania amazonensis. Pi uptake and transcription of LamPho84 gene are differentially regulated during parasite life cycle. Our data suggest that Pi acquisition could be a pivotal task for the success of the parasite throughout its life cycle.
ISSN:0166-6851
1872-9428
DOI:10.1016/j.molbiopara.2019.111212