Prenatal exposure to traffic-related air pollution, the gestational epigenetic clock, and risk of early-life allergic sensitization

[...]when estimating the direct effect of air pollution (ie, adjusting for dGA), an in utero exposure increase of 10 μg/m3 NO2 was associated with a 34% increased risk of allergic sensitization (odds ratio, 1.34; 95% CI, 0.97-1.87), compared with the 42% increase (odds ratio, 1.42; 95% CI, 1.02-1.99...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2019-12, Vol.144 (6), p.1729-1731.e5
Main Authors: Sbihi, Hind, Jones, Meaghan J., MacIsaac, Julie L., Brauer, Michael, Allen, Ryan W., Sears, Malcolm R., Subbarao, Padmaja, Mandhane, Piush J., Moraes, Theo J., Azad, Meghan B., Becker, Allan B., Brook, Jeffrey R., Kobor, Michael S., Turvey, Stuart E.
Format: Article
Language:English
Subjects:
Age
Air pollution
Air pollution effects
Algorithms
Allergies
Antibiotics
Asthma
Biomarkers
Birth weight
Children & youth
Diabetes
DNA methylation
Epigenetics
Ethnicity
Exposure
Intrauterine exposure
Nitrogen dioxide
Pollution
Pollution effects
Pregnancy
Prenatal experience
Prenatal exposure
Studies
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Summary:[...]when estimating the direct effect of air pollution (ie, adjusting for dGA), an in utero exposure increase of 10 μg/m3 NO2 was associated with a 34% increased risk of allergic sensitization (odds ratio, 1.34; 95% CI, 0.97-1.87), compared with the 42% increase (odds ratio, 1.42; 95% CI, 1.02-1.99) without dGA adjustment (see Table E2 in this article's Online Repository at www.jacionline.org). [...]the environmental exposures were rigorously assessed at the individual's reported home addresses throughout pregnancy up to the time of birth. [...]we report data that indicate an important trend where prenatal exposure to TRAP is linked to an increased risk of allergic sensitization, which is potentially mediated by altering the gestational epigenetic clock. [...]dGA was tested against allergic sensitization.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2019.07.047