Radiologic Considerations and Standardization of Malignant Pleural Mesothelioma Imaging Within Clinical Trials: Consensus Statement from the NCI Thoracic Malignancy Steering Committee – International Association for the Study of Lung Cancer – Mesothelioma Applied Research Foundation Clinical Trials Planning Meeting

• Published in: Journal of thoracic oncology 2019-10, Vol.14 (10), p.1718-1731
• Main Authors: Gill, Ritu R., Tsao, Anne S., Kindler, Hedy L., Richards, William G, Armato, Samuel G., Francis, Roslyn J., Gomez, Daniel R., Dahlberg, Suzanne, Rimner, Andreas, Simone, Charles B., de Perrot, Marc, Blumenthal, Gideon, Adjei, Alex A., Bueno, Raphael, Harpole, David H., Hesdorffer, Mary, Hirsch, Fred R., Pass, Harvey I., Yorke, Ellen, Rosenzweig, Kenneth, Burt, Bryan, Fennell, Dean A., Lindwasser, Wolf, Malik, Shakun, Peikert, Tobias, Mansfield, Aaron S., Salgia, Ravi, Yang, Haining, Rusch, Valerie W., Nowak, Anna K.
• Format: Article
• Language: English
• Subjects: Clinical Trials as Topic - standards; Consensus; Diagnostic Imaging - standards; Humans; Lung Neoplasms - diagnosis; Lung Neoplasms - diagnostic imaging; Lung Neoplasms - therapy; Mesothelioma - diagnosis; Mesothelioma - diagnostic imaging; Mesothelioma - therapy; Mesothelioma, Malignant; Multimodal Imaging - standards; National Cancer Institute (U.S.); Pleural Neoplasms - diagnosis; Pleural Neoplasms - diagnostic imaging; Pleural Neoplasms - therapy; Practice Guidelines as Topic - standards; Thoracic Neoplasms - diagnosis; Thoracic Neoplasms - diagnostic imaging; Thoracic Neoplasms - therapy; United States
• ISSN: 1556-0864; 1556-1380
• DOI: 10.1016/j.jtho.2019.08.012

Detailed guidelines pertaining to radiological assessment of malignant pleural mesothelioma are currently lacking due to the rarity of the disease, complex morphology, propensity to invade multiple planes simultaneously, and lack of specific recommendations within the radiology community about assessment, reporting, and follow-up. In March 2017, a multidisciplinary meeting of mesothelioma experts was co-sponsored by the National Cancer Institute Thoracic Malignancy Steering Committee, International Association for the Study of Lung Cancer, and the Mesothelioma Applied Research Foundation. One of the outcomes of this conference was the foundation of detailed, multidisciplinary consensus imaging and management guidelines. Here, we present the recommendations for radiologic assessment of malignant pleural mesothelioma in the setting of clinical trial enrollment. We discuss optimization of imaging parameters across modalities, standardized reporting, and response assessment within clinical trials.