Novel Target Selection for Nuclear Medicine Studies

Nuclear medicine techniques involving SPECT and PET are being increasingly used as a noninvasive tool for the detection, quantitation and therapy response monitoring of a myriad of disease processes through target visualization and kinetic modeling. The target selection requires a good understanding...

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Bibliographic Details
Published in:Seminars in nuclear medicine 2019-09, Vol.49 (5), p.357-368
Main Authors: Lee, Sze Ting, Burvenich, I., Scott, A.M.
Format: Article
Language:English
Subjects:
Diagnostic Imaging
Humans
Molecular Targeted Therapy
Nuclear Medicine - methods
Radiopharmaceuticals - metabolism
Radiopharmaceuticals - therapeutic use
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Summary:Nuclear medicine techniques involving SPECT and PET are being increasingly used as a noninvasive tool for the detection, quantitation and therapy response monitoring of a myriad of disease processes through target visualization and kinetic modeling. The target selection requires a good understanding of the physiologic changes involved in the disease processes. The target selected can range from cellular proteins expressed in a particular organ, biochemical pathways in cells, or receptors on circulating blood cells. This can have a significant impact on therapeutic options for subsequent therapies, including radionuclide therapies in this evolving world of theranostic practices, which is outlined in this review.
ISSN:0001-2998
1558-4623
DOI:10.1053/j.semnuclmed.2019.06.004