Research progress on controlled release of various growth factors in bone regeneration

To summarize the research progress of controlled release of angiogenic factors and osteogenic factors in bone tissue engineering. The domestic and abroad literature on the controlled release structure of growth factors during bone regeneration in recent years was extensively reviewed and summarized....

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Bibliographic Details
Published in:Zhongguo xiu fu chong jian wai ke za zhi 2019-06, Vol.33 (6), p.750-755
Main Authors: Ji, Lin, Song, Ziwei, Zeng, Fuhai, Hu, Ming, Chen, Siqi, Qin, Zhongjie, Xia, Delin
Format: Article
Language:Chinese
Subjects:
Bone Regeneration
Delayed-Action Preparations
Microspheres
Osteogenesis
Tissue Engineering
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Summary:To summarize the research progress of controlled release of angiogenic factors and osteogenic factors in bone tissue engineering. The domestic and abroad literature on the controlled release structure of growth factors during bone regeneration in recent years was extensively reviewed and summarized. The sustained-release structure includes direct binding, microsphere-three-dimensional scaffold structure, core-shell structure, layer self-assembly, hydrogel, and gene carrier. A sustained-release system composed of different sustained-release structures combined with different growth factors can promote bone regeneration and angiogenesis. Due to its controllability and persistence, the growth factor sustained-release system has become a research hotspot in bone tissue engineering and has broad application prospects.
ISSN:1002-1892
DOI:10.7507/1002-1892.201901116