Comparison of Acute Versus Subacute Coronary Angiography in Patients With NON-ST-Elevation Myocardial Infarction (from the NONSTEMI Trial)

• Published in: The American journal of cardiology 2019-09, Vol.124 (6), p.825-832
• Main Authors: Rasmussen, Martin B, Stengaard, Carsten, Sørensen, Jacob T, Riddervold, Ingunn S, Søndergaard, Hanne M, Niemann, Troels, Dodt, Karen Kaae, Frost, Lars, Jensen, Tage, Raungaard, Bent, Hansen, Troels M, Giebner, Matthias, Rasmussen, Claus-Henrik, Bøtker, Hans Erik, Kristensen, Steen D, Maeng, Michael, Christiansen, Evald H, Terkelsen, Christian J
• Format: Article
• Language: English
• Subjects: Acute Coronary Syndrome - diagnosis; Aged; Angina pectoris; Angiography; Calcium-binding protein; Cardiology; Congestive heart failure; Coronary Angiography - methods; Coronary Vessels - diagnostic imaging; Denmark - epidemiology; Diagnosis; Electrocardiography; Female; Follow-Up Studies; Health risk assessment; Heart; Heart attacks; Humans; Male; Medical imaging; Medical treatment; Middle Aged; Mortality; Myocardial infarction; Non-ST Elevated Myocardial Infarction - diagnosis; Non-ST Elevated Myocardial Infarction - mortality; Patients; Randomization; Risk groups; Survival Rate - trends; Time Factors; Trinucleotide repeats; Troponin; Troponin T
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2019.06.007

The optimal timing of coronary angiography (CAG) in high-risk patients with acute coronary syndrome without persisting ST-segment elevation (NST-ACS) remains undetermined. The NON-ST-Elevation Myocardial Infarction trial aimed to compare outcomes in NSTE-ACS patients randomized to acute CAG (STEMI-like approach) with patients randomized to medical therapy and subacute CAG. We randomized 496 patients with suspected NST-ACS based on symptoms and significant regional ST depressions and/or elevated point-of-care troponin T (POC-cTnT) (≥50 ng/l) to either acute CAG (