Diversity of human parechovirus in infants and children with acute gastroenteritis in Japan during 2014–2016

A total of 972 stool samples were collected from infants and children with acute gastroenteritis (AGE) in pediatric clinics encompassing six localities (Hokkaido, Tokyo, Shizuoka, Kyoto, Osaka, and Saga) in Japan during the 2-year period from July 2014 to June 2016. Sixty six of the samples (6.8%) w...

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Bibliographic Details
Published in:Infection, genetics and evolution genetics and evolution, 2019-11, Vol.75, p.104001-104001, Article 104001
Main Authors: Pham, Ngan Thi Kim, Thongprachum, Aksara, Shimizu, Yuko, Trinh, Quang Duy, Okitsu, Shoko, Komine-Aizawa, Shihoko, Shimizu, Hiroyuki, Hayakawa, Satoshi, Ushijima, Hiroshi
Format: Article
Language:English
Subjects:
Acute gastroenteritis
Child
Children
Female
Gastroenteritis - epidemiology
Gastroenteritis - history
Gastroenteritis - virology
Genotype
History, 21st Century
HPeV
Humans
Infant
Japan
Japan - epidemiology
Male
Parechovirus - classification
Parechovirus - genetics
Phylogeny
Picornaviridae Infections - epidemiology
Picornaviridae Infections - history
Picornaviridae Infections - virology
Polymerase Chain Reaction
RNA, Viral
Seasons
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Summary:A total of 972 stool samples were collected from infants and children with acute gastroenteritis (AGE) in pediatric clinics encompassing six localities (Hokkaido, Tokyo, Shizuoka, Kyoto, Osaka, and Saga) in Japan during the 2-year period from July 2014 to June 2016. Sixty six of the samples (6.8%) were found to be positive for human parechovirus (HPeV) by multiplex reverse transcriptase-polymerase chain reaction (RT-PCR) and subjected to genotyping based on viral protein 1 (VP1) sequences. Four different HPeV genotypes consisting of HPeV1, -3, -4 and -6 were detected, with HPeV1 clade B being predominant and followed by HPeV3 and -6. The first-time presence of HPeV1 clade A in Japan and rare HPeV4 were noted. This study provides up-to-date information on the genetic diversity of HPeV circulating in Japanese infants and children with AGE. •Genotyping of HPeV from Japanese children with acute gastroenteritis during 2014–2016 was conducted.•Four different HPeV genotypes consisting of HPeV1, −3, −4 and −6 were identified with the predominance of HPeV1 clade B.•The first-time presence of HPeV1 clade A and rare HPeV4 were noted.
ISSN:1567-1348
1567-7257
DOI:10.1016/j.meegid.2019.104001