Advances in tissue engineering of nanocellulose-based scaffolds: A review

•We discussed the tissue engineering applications of nanocellulose-based scaffolds.•We summarized methods to prepare scaffolds such as electrospinning and 3D printing.•We highlighted the repairing and replacement of heart, liver and ophthalmology.•We outlined the challenges and potentials of nanocel...

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Published in:Carbohydrate polymers 2019-11, Vol.224, p.115144-115144, Article 115144
Main Authors: Luo, Huize, Cha, Ruitao, Li, Juanjuan, Hao, Wenshuai, Zhang, Yan, Zhou, Fengshan
Format: Article
Language:English
Subjects:
Cellulose - chemistry
Cellulose - pharmacology
Humans
Nanocrystalline cellulose
Nanofibrillated cellulose
Nanostructures - chemistry
Scaffold
Tissue engineering
Tissue Engineering - methods
Tissue Scaffolds - chemistry
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Summary:•We discussed the tissue engineering applications of nanocellulose-based scaffolds.•We summarized methods to prepare scaffolds such as electrospinning and 3D printing.•We highlighted the repairing and replacement of heart, liver and ophthalmology.•We outlined the challenges and potentials of nanocellulose-based scaffolds. Scaffolds based on nanocellulose (NC) have crucial applications in tissue engineering (TE) owing to the biocompatibility, water absorption, water retention, optical transparency, and chemo-mechanical properties. In this review, we summarize the scaffolds based on nanocellulose, including nanocrystalline cellulose and nanofibrillated cellulose. We compare four representative methods to prepare NC-based scaffolds, containing electrospinning, freeze-drying, 3D printing, and solvent casting. We outline the characteristics of scaffolds obtained by different methods. Our focus is on the applications of NC-based scaffolds to repair, improve or replace damaged tissues and organs, including skin, blood vessel, nerve, skeletal muscle, heart, liver, and ophthalmology. NC-based scaffolds are attractive materials for regeneration of different tissues and organs due to the remarkable features. Finally, we propose the challenges and potentials of NC-based TE scaffolds.
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2019.115144