Synergy between Zwitterionic Polymers and Hyaluronic Acid Enhances Antifouling Performance

Challenges associated with nonspecific adsorption of proteins on sensor surfaces have steered the development of novel antifouling materials and strategies. Inspired by human synovial fluid composition and structure, we designed synergistic antifouling coatings with mixtures of hyaluronic acid (HA)...

Full description

Saved in:
Bibliographic Details
Published in:Langmuir 2019-12, Vol.35 (48), p.15535-15542
Main Authors: Xia, Yinqiang, Adibnia, Vahid, Shan, Cancan, Huang, Renliang, Qi, Wei, He, Zhimin, Xie, Guojun, Olszewski, Mateusz, De Crescenzo, Gregory, Matyjaszewski, Krzysztof, Banquy, Xavier, Su, Rongxin
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Challenges associated with nonspecific adsorption of proteins on sensor surfaces have steered the development of novel antifouling materials and strategies. Inspired by human synovial fluid composition and structure, we designed synergistic antifouling coatings with mixtures of hyaluronic acid (HA) and a zwitterionic bottlebrush polymer (BB). Using a fast and convenient online surface modification method, the polymers were immobilized on the Au surface, significantly increasing its hydrophilicity. Using surface plasmon resonance (SPR), a 10:1 ratio of HA to BB was found optimal to provide the best antifouling performance. Bovine serum albumin (BSA) adsorption on HA-BB coated surfaces was 0.2 ng/cm2, which was 60 times lower than BB or HA alone and 25 times lower than the commonly accepted ultralow adsorption limit (
ISSN:0743-7463
1520-5827
DOI:10.1021/acs.langmuir.9b01876