Lower fecal pH may be a novel indicator of pouchitis after IPAA in patients with FAP or metachronous Lynch syndrome

Background and Objectives To assess whether fecal pH might be an indicator of pouchitis during the postoperative period in hereditary colorectal cancer (CRC) patients who have undergone ileal pouch anal anastomosis (IPAA). Methods Five consecutive daily pH values of stool samples from 31 familial ad...

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Bibliographic Details
Published in:Journal of surgical oncology 2019-12, Vol.120 (7), p.1184-1189
Main Authors: Yang, Liu, Bao, Jun, Jiang, Qian, Yu, Dong‐sheng, Zhong, Jian
Format: Article
Language:English
Subjects:
Adenomatous Polyposis Coli - pathology
Adenomatous Polyposis Coli - surgery
Adult
Cancer surgery
Colorectal cancer
Colorectal Neoplasms, Hereditary Nonpolyposis - pathology
Colorectal Neoplasms, Hereditary Nonpolyposis - surgery
Colorectal surgery
Feces
Feces - chemistry
Female
Follow-Up Studies
Genetic disorders
hereditary colorectal cancer
Humans
Hydrogen-Ion Concentration
IPAA
Male
pH value
Postoperative Complications
pouchitis
Pouchitis - diagnosis
Pouchitis - etiology
Proctocolectomy, Restorative - adverse effects
Prognosis
Retrospective Studies
Survival Rate
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Summary:Background and Objectives To assess whether fecal pH might be an indicator of pouchitis during the postoperative period in hereditary colorectal cancer (CRC) patients who have undergone ileal pouch anal anastomosis (IPAA). Methods Five consecutive daily pH values of stool samples from 31 familial adenomatous polyposis (FAP) patients and 32 metachronous Lynch syndrome patients who underwent IPAA procedures were reviewed. Patients with pouchitis (pouchitis group, n = 22) were compared with patients without pouchitis (nonpouchitis group, n = 41). A receiver operating characteristic (ROC) analysis was performed to determine the indicative potential of fecal pH for pouchitis. A Mantel‐Cox test was also performed to evaluate the survival status of patients with or without pouchitis. Results Pouchitis was noted in 22 (34.9%) of 63 patients after IPAA. The significance of each daily average fecal pH value and the 5‐day overall average fecal pH value was compared between the two groups (P 
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.25699