Topical Application of Teucrium polium Can Improve Wound Healing in Diabetic Rats

Diabetic foot ulcer is one of the major complications among diabetic patients. Several studies have shown that the extract of Teucrium polium (T. polium) is effective in the treatment of diabetic and non-diabetic wounds, as well as burn wounds. The aim of current study was to assess the wound healin...

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Bibliographic Details
Published in:International journal of lower extremity wounds 2020-06, Vol.19 (2), p.132-138
Main Authors: Fallah Huseini, Hasan, Abdolghaffari, Amir Hossein, Ahwazi, Maryam, Jasemi, Eghbal, Yaghoobi, Maryam, Ziaee, Mojtaba
Format: Article
Language:English
Subjects:
Administration, Topical
Animals
Diabetes Mellitus, Experimental - complications
Diabetic Foot - diagnosis
Diabetic Foot - etiology
Diabetic Foot - therapy
Ointment Bases - pharmacology
Phytotherapy - methods
Plant Extracts - administration & dosage
Rats
Rats, Wistar
Teucrium
Treatment Outcome
Wound Healing - drug effects
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Summary:Diabetic foot ulcer is one of the major complications among diabetic patients. Several studies have shown that the extract of Teucrium polium (T. polium) is effective in the treatment of diabetic and non-diabetic wounds, as well as burn wounds. The aim of current study was to assess the wound healing activity of T. polium extract ointment in diabetic rats. Sixty-four male Wistar rats were induced diabetes with alloxan injection (125 mg/kg) and surgical wound induced. The rats were divided into 8 groups of eight rats each: control group, eucerin group, phenytoin group, 2%, 3%, 4%, 5% and 10% T. polium groups. The ointment was dressed on the wound twice a day. The process of wound healing was screened by macroscopy and digitalization on days 14 and 21 and until complete wound healing. There was no infection in the wounds of rats in any groups. The process of wounds healing of the 2%, 3%, 4%, 5%, and 10% T. polium ointments, with phenytoin ointment and base ointment (eucerin) on day 14 and 21, showed that the significant difference between the treatment groups with 4% (P = 0.003), 5% (P = 0.001), 10% (P = 0.001) T. polium ointment and phenytoin ointment group (P = 0.001) compared to eucerin group. The results of this study showed that T. polium extract ointment with a 10% ointment accelerates the wound healing process in diabetic rats and is comparable to the phenytoin group.
ISSN:1534-7346
1552-6941
DOI:10.1177/1534734619868629