A Metabolomic Study of Biomarkers of Habitual Coffee Intake in Four European Countries

Scope The goal of this work is to identify circulating biomarkers of habitual coffee intake using a metabolomic approach, and to investigate their associations with coffee intake in four European countries. Methods and results Untargeted mass spectrometry‐based metabolic profiling is performed on se...

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Bibliographic Details
Published in:Molecular nutrition & food research 2019-11, Vol.63 (22), p.e1900659-n/a
Main Authors: Rothwell, Joseph A., Keski‐Rahkonen, Pekka, Robinot, Nivonirina, Assi, Nada, Casagrande, Corinne, Jenab, Mazda, Ferrari, Pietro, Boutron‐Ruault, Marie‐Christine, Mahamat‐Saleh, Yahya, Mancini, Francesca Romana, Boeing, Heiner, Katzke, Verena, Kühn, Tilman, Niforou, Katerina, Trichopoulou, Antonia, Valanou, Elisavet, Krogh, Vittorio, Mattiello, Amalia, Palli, Domenico, Sacerdote, Carlotta, Tumino, Rosario, Scalbert, Augustin
Format: Article
Language:English
Subjects:
Adult
Aged
Alkaloids - blood
Biomarkers
Biomarkers - blood
Caffeine
Caffeine - blood
Catechol
Coffee
Coffee - metabolism
Correlation
dietary biomarkers
diketopiperazines
Europe
Female
Food processing
Health risk assessment
Health risks
Humans
Male
Mass spectrometry
Mass spectroscopy
Metabolites
Metabolomics
Middle Aged
Nutrition
Prospective Studies
Quinic acid
Sulfates
Theophylline - blood
trigonelline
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Summary:Scope The goal of this work is to identify circulating biomarkers of habitual coffee intake using a metabolomic approach, and to investigate their associations with coffee intake in four European countries. Methods and results Untargeted mass spectrometry‐based metabolic profiling is performed on serum samples from 451 participants of the European Prospective Investigation on Cancer and Nutrition (EPIC) originating from France, Germany, Greece, and Italy. Eleven coffee metabolites are found to be associated with self‐reported habitual coffee intake, including eight more strongly correlated (r = 0.25–0.51, p 
ISSN:1613-4125
1613-4133
DOI:10.1002/mnfr.201900659