Pre-conception status, obstetric outcome and use of medications during pregnancy of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) in Japan: Multi-center retrospective descriptive study

• Published in: Modern rheumatology 2020-09, Vol.30 (5), p.852-861
• Main Authors: Tsuda, Sayaka, Sameshima, Azusa, Sekine, Michikazu, Kawaguchi, Haruna, Fujita, Daisuke, Makino, Shintaro, Morinobu, Akio, Murakawa, Yohko, Matsui, Kiyoshi, Sugiyama, Takao, Watanabe, Mamoru, Suzuki, Yasuo, Nagahori, Masakazu, Murashima, Atsuko, Atsumi, Tatsuya, Oku, Kenji, Mitsuda, Nobuaki, Takei, Syuji, Miyamae, Takako, Takahashi, Naoto, Nakajima, Ken, Saito, Shigeru
• Format: Article
• Language: English
• Subjects: Adult; Arthritis, Rheumatoid - drug therapy; Arthritis, Rheumatoid - epidemiology; Crohn's disease; Female; Humans; Infant, Newborn; Inflammatory Bowel Diseases - drug therapy; Inflammatory Bowel Diseases - epidemiology; Japan; Lupus Erythematosus, Systemic - drug therapy; Lupus Erythematosus, Systemic - epidemiology; Middle Aged; Pre-Eclampsia - epidemiology; Pregnancy; Pregnancy Outcome - epidemiology; rheumatoid arthritis; systemic lupus erythematosus; ulcerative colitis
• ISSN: 1439-7595; 1439-7609
• DOI: 10.1080/14397595.2019.1661592

Objective: To describe the pre-conception status, pregnancy outcomes, and medication prevalence in systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Crohn's disease (CD), and ulcerative colitis (UC). Methods: E-mail-based questionnaire survey for the Japan Maternal Fetal Intensive Care Unit Network hospitals inquiring prevalence and clinical features of SLE, RA, CD and UC complicated pregnancies for 2 years. Results: The number of SLE, RA, CD and UC among 69,810 deliveries was 184, 139, 27 and 178, respectively. Less than half of pregnancies were planned. Assisted reproductive technology (ART) pregnancy rates were higher in SLE, RA and UC than in the general population (11.4, 23.0 and 7.4 vs 5.1%, p