Validation of corneal topographic and aberrometric measurements obtained by color light-emitting diode reflection topography in healthy eyes

• Published in: Graefe's archive for clinical and experimental ophthalmology 2019-11, Vol.257 (11), p.2437-2447
• Main Authors: Piñero, David P., Molina-Martín, Ainhoa, Camps, Vicent J., de Fez, Dolores, Caballero, María Teresa
• Format: Article
• Language: English
• Subjects: Aberrometry - methods; Adolescent; Adult; Aged; Color; Cornea; Cornea - cytology; Corneal Topography - methods; Female; Healthy Volunteers; Humans; Light emitting diodes; Male; Medicine; Medicine & Public Health; Middle Aged; Ophthalmology; Optics; Prospective Studies; Reproducibility of Results; Statistical analysis; Topography; Young Adult
• ISSN: 0721-832X; 1435-702X
• DOI: 10.1007/s00417-019-04453-5

Purpose To evaluate the intrasession repeatability of anterior corneal topographic and aberrometric measurements provided by a color-LED topographer as well as their interchangeability with those provided by a Scheimpflug-based system in healthy eyes. Methods Thirty-five healthy eyes of 35 patients (age, 16–66 years) were enrolled. A complete eye examination was performed in all cases including a complete corneal analysis with the Scheimpflug-based system Pentacam (Oculus Optikgeräte) (one measurement) and the Cassini system (i-Optics) (three consecutive measurements). Intrasession repeatability of the Cassini measurements was assessed with the within-subject standard deviation (S w ) and the intraclass correlation coefficient (ICC). The Bland-Altman analysis was used to evaluate the agreement between both devices. Results Mean S w for keratometric readings was 0.02 mm (ICC ≥ 0.992), ranging between 0.16 and 0.05 D (ICC 0.930–0.978) for anterior and total astigmatic measurements. Mean S w for asphericity and corneal diameter were 0.06 (ICC 0.926) and 0.03 mm (IC 0.997), respectively. Aberrometric parameters showed ICCs ≥ 0.816, except for Z 4 2 (ICC 0.741) and Z 4 4 (ICC 0.544). When comparing devices, statistically significant differences were found for most of topographic and aberrometric data ( p  ≤ 0.044). Likewise, ranges of agreement between devices were clinically relevant (keratometry > 0.06 mm; total astigmatic components > 0.69 D; asphericity 0.35; second-, third-, and fourth-order Zernike terms, more than 0.20, 0.13, and 0.01 μm, respectively). Conclusions Consistent anterior corneal topographic, total corneal astigmatic, and aberrometric measurements are obtained with color-LED topography in healthy eyes, which are not interchangeable with those provided by the Scheimpflug-based topography.