Infliximab for relapsing neurosarcoidosis recurring after kidney transplantation: a case report

Neurological involvement of sarcoidosis is a rare condition, and its occurrence in the context of transplantation is exceptional. Moreover, treatment can be challenging. We report the unusual case of a patient transplanted with a kidney for end-stage renal disease secondary to sarcoidosis who experi...

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Bibliographic Details
Published in:Acta clinica belgica (English ed. Online) 2021-04, Vol.76 (2), p.149-151
Main Authors: Hanset, Nicolas, Tsevi, Mawufemo Yawovi, Duprez, Thierry, Ivanoiu, Adrian, Devresse, Arnaud, Demoulin, Nathalie, Kanaan, Nada
Format: Article
Language:English
Subjects:
Kidney transplants
Monoclonal antibodies
Sarcoidosis
TNF inhibitors
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Summary:Neurological involvement of sarcoidosis is a rare condition, and its occurrence in the context of transplantation is exceptional. Moreover, treatment can be challenging. We report the unusual case of a patient transplanted with a kidney for end-stage renal disease secondary to sarcoidosis who experienced a neurological recurrence of the disease under immunosuppressive treatment, translating in behavioural aggressiveness, social withdrawal and weight loss. He relapsed thrice under corticosteroids but responded finally to infliximab. This case highlights the potential of sarcoidosis to recur neurologically after kidney transplantation despite immunosuppressive treatment. Also, treatment of relapsing neurosarcoidosis can be challenging and may benefit from TNF-α blockers.
ISSN:1784-3286
2295-3337
DOI:10.1080/17843286.2019.1664093