Vibrating tip spray ionization mass spectrometry for direct sample analysis

In this work, a vibrating tip spray ionization source was developed for direct mass spectrometric analysis of raw samples under voltage‐free condition. A solid tip was mounted on a vibrator, and the solid tip was placed on the front of MS inlet. Liquid, viscous, and bulk solid samples could be direc...

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Bibliographic Details
Published in:Journal of mass spectrometry. 2019-09, Vol.54 (9), p.772-779
Main Authors: Yao, Ya‐Nan, Wu, Lin, Di, Dandan, Yuan, Zi‐Cheng, Hu, Bin
Format: Article
Language:English
Subjects:
Analysis
Atomizing
direct sample analysis
Electric potential
Food safety
Forensic science
Forensic sciences
in vivo analysis
Inlets (waterways)
Ionization
Ions
Mass spectrometry
Mass spectroscopy
pharmaceutical analysis
Plants (botany)
Scientific imaging
Sensitivity analysis
Solvents
Spectroscopy
Tissue analysis
Tissues
vibrating tip spray ionization
Vibration
Voltage
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Description
Summary:In this work, a vibrating tip spray ionization source was developed for direct mass spectrometric analysis of raw samples under voltage‐free condition. A solid tip was mounted on a vibrator, and the solid tip was placed on the front of MS inlet. Liquid, viscous, and bulk solid samples could be directly loaded on the tip‐end surface, and then a drop of solvent at microliter level was subsequently loaded on the tip for dissolution and extraction of analytes, and a vibrator was then started to atomize and ionize the analytes under ambient condition. We demonstrated vibrating tip spray mass spectrometry in various applications, including food safety, pharmaceutical analysis, and forensic science. Furthermore, in situ analysis of biological tissues and in vivo analysis of living plants were conveniently performed, due to voltage‐free. Different vibration frequencies and solvent compositions were investigated. The analytical performances, including sensitivity, reproducibility, and linear range, were investigated. The ionization process and mechanism were also discussed in this work.
ISSN:1076-5174
1096-9888
DOI:10.1002/jms.4429