Neurosurgical brain tumor detection based on intraoperative optical intrinsic signal imaging technique: A case report of glioblastoma

The delineation of brain tumor margins has been a challenging objective in neurosurgery for decades. Despite the development of various preoperative imaging techniques, the current methodology is still insufficient for clinical practice. We present an intraoperative optical intrinsic signal imaging...

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Bibliographic Details
Published in:Journal of biophotonics 2020-01, Vol.13 (1), p.e201900200-n/a
Main Authors: Liu, Xin‐Rui, Hsiao, Tien‐Yu, Li, Yun‐Qian, Chiu, Kai‐Shih, Huang, Chun‐Jung, Li, Shan‐Ji, Lin, Ching Po, Zhao, Gang, Sun, Chia‐Wei
Format: Article
Language:English
Subjects:
Blood vessels
Brain
Brain cancer
brain tumor surgery
Brain tumors
Case reports
Data processing
Glioblastoma
Imaging
Imaging techniques
Neuroimaging
Neurosurgery
Optical communication
optical intrinsic signal
Signal processing
Surgery
surgery guiding
Surgical outcomes
Tumors
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Summary:The delineation of brain tumor margins has been a challenging objective in neurosurgery for decades. Despite the development of various preoperative imaging techniques, the current methodology is still insufficient for clinical practice. We present an intraoperative optical intrinsic signal imaging system for brain tumor surgery and establish a data processing procedure model to localize tumors. From the experimental result of a glioblastoma patient, we observe a relative small oscillation of ΔHbD in tumor region and speculate that vessels in tumor region have poor ability to provide oxygen. We applied the same data processing procedure on the second time data and proclaimed a successful surgery. Figure: Merged ΔHbD image captured prior and posterior to tumor removal. Intraoperative neurosurgical diagnosis of brain tumor determines the success rate of patients' prognoses. We first proposed a novel approach based on optical method to distinguish the site of tumor by functional manner. The promoted technique is noninvasive, nonradioactive, dye‐free and potential of real‐time monitoring, which is still not available nowadays by using other techniques. We believe that this method can facilitate clinical examination in the future and greatly elongate the patients' longevity.
ISSN:1864-063X
1864-0648
DOI:10.1002/jbio.201900200