Effect of Glycosaminoglycans on Pathogenic Properties Far-Eastern Tick-Borne Encephalitis Virus

We studied the effect of sulfated glycosaminoglycan on the infection properties of high-virulence Dal’negorsk strain and low-virulence Primorye-437 of tick-borne encephalitis virus. Differences in reproductive activity of these strains and their tropism to the target cells were revealed. Glycosamino...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2019-08, Vol.167 (4), p.482-485
Main Authors: Leonova, G. N., Belikov, S. I.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cell culture
Cell Line
Encephalitis
Encephalitis Viruses, Tick-Borne - drug effects
Encephalitis Viruses, Tick-Borne - pathogenicity
Glycosaminoglycans
Glycosaminoglycans - pharmacology
Health aspects
Internal Medicine
Laboratory Medicine
Pathology
Strains (organisms)
Sulfates
Swine
Tick-borne encephalitis
Tropism
Virion - drug effects
Virulence
Virulence (Microbiology)
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Summary:We studied the effect of sulfated glycosaminoglycan on the infection properties of high-virulence Dal’negorsk strain and low-virulence Primorye-437 of tick-borne encephalitis virus. Differences in reproductive activity of these strains and their tropism to the target cells were revealed. Glycosaminoglycan reduced pathogenetic activity of high-virulence strain in vitro , but had no effect on low-virulence strain. The interaction of imperfect virus particles of non-pathogen strain with the glycosaminoglycan led to their accumulation in cell, but in the culture medium of SPEV cells infected with experimental and control samples, accumulation of virus particles did not differ. The results on activity of glycosaminoglycan binding with strains differing by their biological and molecular genetic characteristics can be used to assess their pathogenic potential.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-019-04555-4