Hierarchical Functionalized Polymeric‐Ceramic Coatings on Mg‐Ca Alloys for Biodegradable Implant Applications

• Published in: Macromolecular bioscience 2019-10, Vol.19 (10), p.e1900179-n/a
• Main Authors: Santos‐Coquillat, Ana, Martínez‐Campos, Enrique, Vargas‐Alfredo, Nelson, Arrabal, Raúl, Rodríguez‐Hernández, Juan, Matykina, Endzhe
• Format: Article
• Language: English
• Subjects: Absorbable Implants; Adhesion; Alloys - chemistry; Alloys - pharmacology; Animals; Biocompatibility; Biodegradability; biodegradable implants; Biodegradation; breath figures; Calcium; Calcium - chemistry; Calcium - pharmacology; Cell adhesion; Cell adhesion & migration; Cell Adhesion - drug effects; Cell culture; Cell Line; Cell Proliferation - drug effects; Ceramic coatings; Ceramic glazes; Ceramics; Ceramics - chemistry; Ceramics - pharmacology; Coated Materials, Biocompatible - chemistry; Coated Materials, Biocompatible - pharmacology; Coatings; Degradability; Degradation; Degradation products; hierarchical structures; Implantation; Implants; Magnesium; Magnesium - chemistry; Magnesium - pharmacology; Magnesium base alloys; Materials Testing; Mice; Oxidation; Polyesters - chemistry; Polyesters - pharmacology; polymer–inorganic hybrid coatings; Porosity; Protective coatings; Scaffolds; Therapeutic applications; Transplants & implants
• ISSN: 1616-5187; 1616-5195
• DOI: 10.1002/mabi.201900179

Magnesium‐based implants present several advantages for clinical applications, in particular due to their biocompatibility and degradability. However, degradation products can affect negatively the cell activity. In this work, a combined coating strategy to control the implant degradation and cell regulation processes is evaluated, including plasma electrolytic oxidation (PEO) that produces a 13 µm‐thick Ca, P, and Si containing ceramic coating with surface porosity, and breath figures (BF) approach that produces a porous polymeric poly(ε‐caprolactone) surface. The degradation of PCL‐PEO‐coated Mg hierarchical scaffold can be tailored to promote cell adhesion and proliferation into the porous structure. As a result, cell culture can colonize the inner PEO‐ceramic coating structure where higher amount of bioelements are present. The Mg/PEO/PCL/BF scaffolds exhibit equally good or better premyoblast cell adhesion and proliferation compared with Ti CP control. The biological behavior of this new hierarchical functionalized scaffold can improve the implantation success in bone and cardiovascular clinical applications. A combination of plasma electrolytic oxidation coating and breath figure textured polymeric poly(ε‐caprolactone) layer is used to form a hierarchical porous structure on biodegradable Mg‐Ca alloy for bone and cardiovascular clinical applications. 3D porous scaffold induces hierarchical coating colonization by cells that penetrate the polymer pores and anchor to the underlying Ca‐, P‐, and Si‐enriched MgO ceramic layer.