Midpregnancy testing for soluble fms-like tyrosine kinase 1 (sFlt-1) and placental growth factor (PlGF): An inter-assay comparison of three automated immunoassay platforms

We performed an inter-assay comparison among three immunoassay platforms for midpregnancy testing of sFlt-1, PlGF and the sFlt-1/PlGF ratio, which are established markers for pre-eclampsia. Maternal blood was collected 19–22 weeks’ gestation. Raw data values were converted to multiples of the median...

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Bibliographic Details
Published in:Placenta (Eastbourne) 2019-10, Vol.86, p.11-14
Main Authors: Black, Carin, Al-Amin, Ahmed, Rolnik, Daniel Lorber, Kane, Stefan C., Stolarek, Caroline, White, Adrienne, da Silva Costa, Fabricio, Brennecke, Shaun
Format: Article
Language:English
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Summary:We performed an inter-assay comparison among three immunoassay platforms for midpregnancy testing of sFlt-1, PlGF and the sFlt-1/PlGF ratio, which are established markers for pre-eclampsia. Maternal blood was collected 19–22 weeks’ gestation. Raw data values were converted to multiples of the median (MoM). PlGF and sFlt-1 values among platforms were highly correlated (p 
ISSN:0143-4004
1532-3102
DOI:10.1016/j.placenta.2019.08.083