Protective effects of modafinil administration on testicular torsion/detorsion damage in rats

Testicular torsion is a pathological condition which leads to sever scrotal pain and ischemia. After surgical reperfusion, oxidative stress factors cause to germ cell apoptosis. Thus, adjuvant therapy to surgery should be useful to decrease of ischemia/reperfusion (I/R) injury of testis. Modafinil,...

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Bibliographic Details
Published in:Experimental and molecular pathology 2019-12, Vol.111, p.104305-104305, Article 104305
Main Authors: Yousefi-Manesh, Hasan, Shirooie, Samira, Hemati, Sara, Shokrian-Zeini, Mohadeseh, Zarei, Nazanin, Raoufi, Mojtaba, Farrokhi, Vida, Dehpour, Ahmad Reza
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Central Nervous System Stimulants - pharmacology
Inflammation
Male
Modafinil
Modafinil - administration & dosage
Modafinil - pharmacology
Oxidative Stress
Protective Agents - pharmacology
Rat
Rats
Rats, Wistar
Reperfusion
Reperfusion Injury - drug therapy
Reperfusion Injury - etiology
Spermatic Cord Torsion - complications
Spermatic Cord Torsion - drug therapy
Testicular torsion
Testis - drug effects
Testis - metabolism
Testis - pathology
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Summary:Testicular torsion is a pathological condition which leads to sever scrotal pain and ischemia. After surgical reperfusion, oxidative stress factors cause to germ cell apoptosis. Thus, adjuvant therapy to surgery should be useful to decrease of ischemia/reperfusion (I/R) injury of testis. Modafinil, a drug to treat sleepiness, has been indicated to have anti-inflammatory effects. The aim was to evaluate the efficiency of modafinil administration after reperfusion surgery in a rat model of testicular torsion/detorsion (T/D). Male wistar rats were divided into three groups and each group contained 10 animals. To induce torsion right testis was rotated 720° clockwise and was left for 1 h. Modafinil group received modafinil (10 mg/kg) once daily intraperitoneally for 7 days after the surgery and the control group received physiologic saline once daily intraperitoneally for 7 days after the surgery. Thereafter, MDA, IL-1β and TNF-α levels and histopathological changes were investigated. MDA, IL-1β and TNF-α levels significantly increased in T/D group compared to the control group (⁎⁎P 
ISSN:0014-4800
1096-0945
DOI:10.1016/j.yexmp.2019.104305