Change in visual acuity 12 and 24 months after transscleral ab interno glaucoma gel stent implantation with adjunctive Mitomycin C

• Published in: Graefe's archive for clinical and experimental ophthalmology 2019-12, Vol.257 (12), p.2707-2715
• Main Authors: Lenzhofer, Markus, Strohmaier, Clemens, Hohensinn, Melchior, Hitzl, Wolfgang, Steiner, Veit, Baca, Björn, Moussa, Sarah, Motloch, Karolina, Reitsamer, Herbert A.
• Format: Article
• Language: English
• Subjects: Acuity; Cataracts; Eye; Glaucoma; Implants; Medicine; Medicine & Public Health; Mitomycin C; Ophthalmology; Risk factors; Stents; Surgery; Visual acuity
• ISSN: 0721-832X; 1435-702X
• DOI: 10.1007/s00417-019-04452-6

Purpose To analyze changes in best-corrected visual acuity (BCVA) after implantation of the transscleral ab interno glaucoma gel stent (XEN Gel Stent; Allergan, Dublin) in patients with open-angle glaucoma. Methods In a single-center, prospective, non-randomized study of 137 eyes with open-angle glaucoma which underwent implantation with XEN, 69 eyes underwent XEN implantation alone (group 1) and 68 eyes underwent XEN implantation and cataract surgery (group 2). BCVA (Bailey–Lovie chart, logMAR scale) was evaluated at baseline, postoperative day 1, weeks 1 and 2, and months 1, 3, 6, 12, and 24. Risk factors for decline in BCVA were analyzed in multivariate models. Results Baseline BCVA in group 1 was 0.21 ± 031; the group’s mean BCVA did not change at any postoperative visit, although a ≥ 2-line loss of BCVA was detected in 15% (95% CI 7–29%) and 4% (95% CI 0–20%) after months 12 and 24, respectively. Baseline BCVA in group 2 was 0.33 ± 031; vision increased significantly at months 3 (0.22 ± 0.29, p  = 0.015), 6 (0.20 ± 0.26, p  = 0.006), 12 (0.18 ± 0.29, p  = 0.001), and 24 (0.18 ± 0.29, p  = 0.005). A ≥ 2-line loss of BCVA was reported in 4% (95% CI 1–15%) and 7% (95% CI 1–24%) after months 12 and 24, respectively. Conclusions There was no deterioration of BCVA in group 1; those in group 2 had an overall significant increase in BCVA. BCVA decrease was lower than is typically reported in the literature post-trabeculectomy.