Death after misuse of anabolic substances (clenbuterol, stanozolol and metandienone)

•Quantification of stanozolol and metandienone in post-mortem femoral blood.•Detection of boldenone, clomiphene, trenbolone, clenbuterol, and drostanolone.•Detection of clenbuterol in post-mortem femoral blood.•Comprehensive literature review of clenbuterol. A 34-year old male was found breathless a...

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Bibliographic Details
Published in:Forensic science international 2019-10, Vol.303, p.109925-109925, Article 109925
Main Authors: Lehmann, Sabrina, Thomas, Andreas, Schiwy-Bochat, Karl-Heinz, Geyer, Hans, Thevis, Mario, Glenewinkel, Frank, Rothschild, Markus Alexander, Andresen-Streichert, Hilke, Juebner, Martin
Format: Article
Language:English
Subjects:
Adult
Anabolic Agents - adverse effects
Anabolic Agents - analysis
Anabolic-androgenic steroids
Androstanols - urine
Autopsies
Autopsy
Bodybuilding
Chromatography
Clenbuterol
Clenbuterol - adverse effects
Clenbuterol - analysis
Clomiphene
Clomiphene - urine
Congenital diseases
Coronary artery
Coronary vessels
Coronary Vessels - pathology
Death
Doping agents
Doping in Sports
Edema
Fatal Outcome
Fatalities
Forensic sciences
Heart
Heart Failure - chemically induced
Humans
Hypertrophy
Hypertrophy, Left Ventricular - pathology
Legal medicine
Male
Mass spectrometry
Medical equipment
Methandrostenolone - adverse effects
Methandrostenolone - analysis
Multi-drug abuse
Organic chemistry
Risk analysis
Risk factors
Scientific imaging
Stanozolol
Stanozolol - adverse effects
Stanozolol - analysis
Steroid hormones
Steroids
Testosterone
Testosterone - analogs & derivatives
Testosterone - urine
Thyroid gland
Trenbolone
Trenbolone Acetate - blood
Trenbolone Acetate - urine
Urine
Ventricle
Writing
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Summary:•Quantification of stanozolol and metandienone in post-mortem femoral blood.•Detection of boldenone, clomiphene, trenbolone, clenbuterol, and drostanolone.•Detection of clenbuterol in post-mortem femoral blood.•Comprehensive literature review of clenbuterol. A 34-year old male was found breathless and panting at home by his girlfriend three hours after a gym workout. Minutes later, he collapsed and died. Autopsy, histological and chemical analyses were conducted. The examination of the heart showed left ventricular hypertrophy, while the right coronary artery showed only a small vascular lumen (3 mm in diameter), due to its anatomical structure. In femoral blood concentrations of approx. 1 μg/L clenbuterol, approx. 56 μg/L stanozolol and approx. 8 μg/L metandienone, with trenbolone (
ISSN:0379-0738
1872-6283
DOI:10.1016/j.forsciint.2019.109925