The Incremental Risk of Pancreatic Cancer According to Fasting Glucose Levels: Nationwide Population-Based Cohort Study

Abstract Context It has been unclear whether the risk of pancreatic cancer is different according to glucose levels. Objective To determine the association between fasting glucose levels and pancreatic cancer risk using prospectively collected nationwide population-based cohort data in Korea. Design...

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Bibliographic Details
Published in:The journal of clinical endocrinology and metabolism 2019-10, Vol.104 (10), p.4594-4599
Main Authors: Koo, Dong-Hoe, Han, Kyung-Do, Park, Cheol-Young
Format: Article
Language:English
Subjects:
Blood sugar
Body mass index
Cancer
Cohort analysis
Diabetes
Diabetes mellitus
Fasting
Glucose
Health risk assessment
Hypoglycemic agents
National health insurance
Oncology, Experimental
Pancreatic cancer
Population studies
Population-based studies
Prediabetic state
Risk factors
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Summary:Abstract Context It has been unclear whether the risk of pancreatic cancer is different according to glucose levels. Objective To determine the association between fasting glucose levels and pancreatic cancer risk using prospectively collected nationwide population-based cohort data in Korea. Design The National Health Insurance Service database of claims and preventive health check-up data recorded was used between 2009 and 2015. Setting and Participants A total of 25.4 million patients who had participated in a preventive health check-up between 2009 and 2013 were evaluated for pancreatic cancer incidence rates according to fasting glucose level. Main Outcomes Measures The cumulative incidence rate for pancreatic cancer was calculated after grouping according to fasting glucose levels as follows: (i) low normal (
ISSN:0021-972X
1945-7197
DOI:10.1210/jc.2019-00033