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The Incremental Risk of Pancreatic Cancer According to Fasting Glucose Levels: Nationwide Population-Based Cohort Study
Abstract Context It has been unclear whether the risk of pancreatic cancer is different according to glucose levels. Objective To determine the association between fasting glucose levels and pancreatic cancer risk using prospectively collected nationwide population-based cohort data in Korea. Design...
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| Published in: | The journal of clinical endocrinology and metabolism 2019-10, Vol.104 (10), p.4594-4599 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c5023-863b84980ce744326d0e6417ea6bbb4ead48f53d4c4ff16aeb2432d7a82ed7bb3 |
| container_end_page | 4599 |
| container_issue | 10 |
| container_start_page | 4594 |
| container_title | The journal of clinical endocrinology and metabolism |
| container_volume | 104 |
| creator | Koo, Dong-Hoe Han, Kyung-Do Park, Cheol-Young |
| description | Abstract
Context
It has been unclear whether the risk of pancreatic cancer is different according to glucose levels.
Objective
To determine the association between fasting glucose levels and pancreatic cancer risk using prospectively collected nationwide population-based cohort data in Korea.
Design
The National Health Insurance Service database of claims and preventive health check-up data recorded was used between 2009 and 2015.
Setting and Participants
A total of 25.4 million patients who had participated in a preventive health check-up between 2009 and 2013 were evaluated for pancreatic cancer incidence rates according to fasting glucose level.
Main Outcomes Measures
The cumulative incidence rate for pancreatic cancer was calculated after grouping according to fasting glucose levels as follows: (i) low normal ( |
| doi_str_mv | 10.1210/jc.2019-00033 |
| format | article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2288005781</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A690300778</galeid><oup_id>10.1210/jc.2019-00033</oup_id><sourcerecordid>A690300778</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5023-863b84980ce744326d0e6417ea6bbb4ead48f53d4c4ff16aeb2432d7a82ed7bb3</originalsourceid><addsrcrecordid>eNp1kc1vEzEQxVcIREPhyBVZ4sJlg7927eUWIloqRVBBkbhZXnu22dRZB9tL1P8eb5OCqEA-eDz6vTcjv6J4SfCcUILfbsycYtKUGGPGHhUz0vCqFKQRj4sZxpSUjaDfT4pnMW4wJpxX7GlxwghvpBR4Vuyv1oAuBhNgC0PSDn3p4w3yHbrUU1On3qBlLiGghTE-2H64RsmjMx3TVJ670fgIaAU_wcV36FNW-GHfW0CXfje6u2f5XkewaOnXPiT0NY329nnxpNMuwovjfVp8O_twtfxYrj6fXywXq9JUmLJS1qyVeVdsQHDOaG0x1JwI0HXbthy05bKrmOWGdx2pNbQ0U1ZoScGKtmWnxZuD7y74HyPEpLZ9NOCcHsCPUVEqJcaVkCSjrx-gGz-GIW-nKKs5ZZUk9R_qWjtQ_dD5FLSZTNWibjDDWAiZqfk_qHwsbHvjB-j63P9LUB4EJvgYA3RqF_qtDreKYDUFrTZGTUGru6Az_-q47Nhuwf6m75PNADkAe-8ShHjjxj0EtQbt0vqhaXlvevwsP-7-N_-I_gLZjb2n</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2364235816</pqid></control><display><type>article</type><title>The Incremental Risk of Pancreatic Cancer According to Fasting Glucose Levels: Nationwide Population-Based Cohort Study</title><source>Oxford University Press:Jisc Collections:OUP Read and Publish 2024-2025 (2024 collection) (Reading list)</source><creator>Koo, Dong-Hoe ; Han, Kyung-Do ; Park, Cheol-Young</creator><creatorcontrib>Koo, Dong-Hoe ; Han, Kyung-Do ; Park, Cheol-Young</creatorcontrib><description>Abstract
Context
It has been unclear whether the risk of pancreatic cancer is different according to glucose levels.
Objective
To determine the association between fasting glucose levels and pancreatic cancer risk using prospectively collected nationwide population-based cohort data in Korea.
Design
The National Health Insurance Service database of claims and preventive health check-up data recorded was used between 2009 and 2015.
Setting and Participants
A total of 25.4 million patients who had participated in a preventive health check-up between 2009 and 2013 were evaluated for pancreatic cancer incidence rates according to fasting glucose level.
Main Outcomes Measures
The cumulative incidence rate for pancreatic cancer was calculated after grouping according to fasting glucose levels as follows: (i) low normal (<90 mg/dL), (ii) high normal (90 to 99 mg/dL), (iii) prediabetes level 1 (100 to 109 mg/dL), (iv) prediabetes level 2 (110 to 125 mg/dL), (v) diabetes (≥126 mg/dL), and (vi) diabetes on anti-diabetic medications.
Results
The 5-year cumulative incidence rates (per 100,000) were as follows: (i) low normal = 32; (ii) high normal = 41; (iii) prediabetes level 1 = 50; (iv) prediabetes level 2 = 64; (v) diabetes = 75; and (vi) on anti-diabetic medications = 121. The risk of pancreatic cancer increased continuously with elevating fasting glucose levels (P < 0.0001). The incidence of pancreatic cancer increased significantly with increasing fasting blood glucose levels even after adjusting for age, sex, smoking, drinking, exercise, body mass index, and diabetes duration (P < 0.0001).
Conclusions
The cumulative incidence rate of pancreatic cancer significantly increased as the fasting glucose level elevated, even in populations with a normal glucose level range.
As the fasting glucose level elevated, the incidence of pancreatic cancer significantly increased, not only in diabetic populations but also in those with prediabetes or normal glucose levels.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2019-00033</identifier><identifier>PMID: 31498870</identifier><language>eng</language><publisher>Washington, DC: Endocrine Society</publisher><subject>Blood sugar ; Body mass index ; Cancer ; Cohort analysis ; Diabetes ; Diabetes mellitus ; Fasting ; Glucose ; Health risk assessment ; Hypoglycemic agents ; National health insurance ; Oncology, Experimental ; Pancreatic cancer ; Population studies ; Population-based studies ; Prediabetic state ; Risk factors</subject><ispartof>The journal of clinical endocrinology and metabolism, 2019-10, Vol.104 (10), p.4594-4599</ispartof><rights>Copyright © 2019 Endocrine Society 2019</rights><rights>Copyright © Oxford University Press 2015</rights><rights>Copyright © 2019 Endocrine Society.</rights><rights>COPYRIGHT 2019 Oxford University Press</rights><rights>Copyright © 2019 Endocrine Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5023-863b84980ce744326d0e6417ea6bbb4ead48f53d4c4ff16aeb2432d7a82ed7bb3</citedby><cites>FETCH-LOGICAL-c5023-863b84980ce744326d0e6417ea6bbb4ead48f53d4c4ff16aeb2432d7a82ed7bb3</cites><orcidid>0000-0002-9415-9965 ; 0000-0001-9913-8883</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31498870$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koo, Dong-Hoe</creatorcontrib><creatorcontrib>Han, Kyung-Do</creatorcontrib><creatorcontrib>Park, Cheol-Young</creatorcontrib><title>The Incremental Risk of Pancreatic Cancer According to Fasting Glucose Levels: Nationwide Population-Based Cohort Study</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Abstract
Context
It has been unclear whether the risk of pancreatic cancer is different according to glucose levels.
Objective
To determine the association between fasting glucose levels and pancreatic cancer risk using prospectively collected nationwide population-based cohort data in Korea.
Design
The National Health Insurance Service database of claims and preventive health check-up data recorded was used between 2009 and 2015.
Setting and Participants
A total of 25.4 million patients who had participated in a preventive health check-up between 2009 and 2013 were evaluated for pancreatic cancer incidence rates according to fasting glucose level.
Main Outcomes Measures
The cumulative incidence rate for pancreatic cancer was calculated after grouping according to fasting glucose levels as follows: (i) low normal (<90 mg/dL), (ii) high normal (90 to 99 mg/dL), (iii) prediabetes level 1 (100 to 109 mg/dL), (iv) prediabetes level 2 (110 to 125 mg/dL), (v) diabetes (≥126 mg/dL), and (vi) diabetes on anti-diabetic medications.
Results
The 5-year cumulative incidence rates (per 100,000) were as follows: (i) low normal = 32; (ii) high normal = 41; (iii) prediabetes level 1 = 50; (iv) prediabetes level 2 = 64; (v) diabetes = 75; and (vi) on anti-diabetic medications = 121. The risk of pancreatic cancer increased continuously with elevating fasting glucose levels (P < 0.0001). The incidence of pancreatic cancer increased significantly with increasing fasting blood glucose levels even after adjusting for age, sex, smoking, drinking, exercise, body mass index, and diabetes duration (P < 0.0001).
Conclusions
The cumulative incidence rate of pancreatic cancer significantly increased as the fasting glucose level elevated, even in populations with a normal glucose level range.
As the fasting glucose level elevated, the incidence of pancreatic cancer significantly increased, not only in diabetic populations but also in those with prediabetes or normal glucose levels.</description><subject>Blood sugar</subject><subject>Body mass index</subject><subject>Cancer</subject><subject>Cohort analysis</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Fasting</subject><subject>Glucose</subject><subject>Health risk assessment</subject><subject>Hypoglycemic agents</subject><subject>National health insurance</subject><subject>Oncology, Experimental</subject><subject>Pancreatic cancer</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Prediabetic state</subject><subject>Risk factors</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kc1vEzEQxVcIREPhyBVZ4sJlg7927eUWIloqRVBBkbhZXnu22dRZB9tL1P8eb5OCqEA-eDz6vTcjv6J4SfCcUILfbsycYtKUGGPGHhUz0vCqFKQRj4sZxpSUjaDfT4pnMW4wJpxX7GlxwghvpBR4Vuyv1oAuBhNgC0PSDn3p4w3yHbrUU1On3qBlLiGghTE-2H64RsmjMx3TVJ670fgIaAU_wcV36FNW-GHfW0CXfje6u2f5XkewaOnXPiT0NY329nnxpNMuwovjfVp8O_twtfxYrj6fXywXq9JUmLJS1qyVeVdsQHDOaG0x1JwI0HXbthy05bKrmOWGdx2pNbQ0U1ZoScGKtmWnxZuD7y74HyPEpLZ9NOCcHsCPUVEqJcaVkCSjrx-gGz-GIW-nKKs5ZZUk9R_qWjtQ_dD5FLSZTNWibjDDWAiZqfk_qHwsbHvjB-j63P9LUB4EJvgYA3RqF_qtDreKYDUFrTZGTUGru6Az_-q47Nhuwf6m75PNADkAe-8ShHjjxj0EtQbt0vqhaXlvevwsP-7-N_-I_gLZjb2n</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>Koo, Dong-Hoe</creator><creator>Han, Kyung-Do</creator><creator>Park, Cheol-Young</creator><general>Endocrine Society</general><general>Copyright Oxford University Press</general><general>Oxford University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7T5</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9415-9965</orcidid><orcidid>https://orcid.org/0000-0001-9913-8883</orcidid></search><sort><creationdate>20191001</creationdate><title>The Incremental Risk of Pancreatic Cancer According to Fasting Glucose Levels: Nationwide Population-Based Cohort Study</title><author>Koo, Dong-Hoe ; Han, Kyung-Do ; Park, Cheol-Young</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5023-863b84980ce744326d0e6417ea6bbb4ead48f53d4c4ff16aeb2432d7a82ed7bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Blood sugar</topic><topic>Body mass index</topic><topic>Cancer</topic><topic>Cohort analysis</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Fasting</topic><topic>Glucose</topic><topic>Health risk assessment</topic><topic>Hypoglycemic agents</topic><topic>National health insurance</topic><topic>Oncology, Experimental</topic><topic>Pancreatic cancer</topic><topic>Population studies</topic><topic>Population-based studies</topic><topic>Prediabetic state</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koo, Dong-Hoe</creatorcontrib><creatorcontrib>Han, Kyung-Do</creatorcontrib><creatorcontrib>Park, Cheol-Young</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koo, Dong-Hoe</au><au>Han, Kyung-Do</au><au>Park, Cheol-Young</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Incremental Risk of Pancreatic Cancer According to Fasting Glucose Levels: Nationwide Population-Based Cohort Study</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2019-10-01</date><risdate>2019</risdate><volume>104</volume><issue>10</issue><spage>4594</spage><epage>4599</epage><pages>4594-4599</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><abstract>Abstract
Context
It has been unclear whether the risk of pancreatic cancer is different according to glucose levels.
Objective
To determine the association between fasting glucose levels and pancreatic cancer risk using prospectively collected nationwide population-based cohort data in Korea.
Design
The National Health Insurance Service database of claims and preventive health check-up data recorded was used between 2009 and 2015.
Setting and Participants
A total of 25.4 million patients who had participated in a preventive health check-up between 2009 and 2013 were evaluated for pancreatic cancer incidence rates according to fasting glucose level.
Main Outcomes Measures
The cumulative incidence rate for pancreatic cancer was calculated after grouping according to fasting glucose levels as follows: (i) low normal (<90 mg/dL), (ii) high normal (90 to 99 mg/dL), (iii) prediabetes level 1 (100 to 109 mg/dL), (iv) prediabetes level 2 (110 to 125 mg/dL), (v) diabetes (≥126 mg/dL), and (vi) diabetes on anti-diabetic medications.
Results
The 5-year cumulative incidence rates (per 100,000) were as follows: (i) low normal = 32; (ii) high normal = 41; (iii) prediabetes level 1 = 50; (iv) prediabetes level 2 = 64; (v) diabetes = 75; and (vi) on anti-diabetic medications = 121. The risk of pancreatic cancer increased continuously with elevating fasting glucose levels (P < 0.0001). The incidence of pancreatic cancer increased significantly with increasing fasting blood glucose levels even after adjusting for age, sex, smoking, drinking, exercise, body mass index, and diabetes duration (P < 0.0001).
Conclusions
The cumulative incidence rate of pancreatic cancer significantly increased as the fasting glucose level elevated, even in populations with a normal glucose level range.
As the fasting glucose level elevated, the incidence of pancreatic cancer significantly increased, not only in diabetic populations but also in those with prediabetes or normal glucose levels.</abstract><cop>Washington, DC</cop><pub>Endocrine Society</pub><pmid>31498870</pmid><doi>10.1210/jc.2019-00033</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-9415-9965</orcidid><orcidid>https://orcid.org/0000-0001-9913-8883</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | The journal of clinical endocrinology and metabolism, 2019-10, Vol.104 (10), p.4594-4599 |
| issn | 0021-972X 1945-7197 |
| language | eng |
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| source | Oxford University Press:Jisc Collections:OUP Read and Publish 2024-2025 (2024 collection) (Reading list) |
| subjects | Blood sugar Body mass index Cancer Cohort analysis Diabetes Diabetes mellitus Fasting Glucose Health risk assessment Hypoglycemic agents National health insurance Oncology, Experimental Pancreatic cancer Population studies Population-based studies Prediabetic state Risk factors |
| title | The Incremental Risk of Pancreatic Cancer According to Fasting Glucose Levels: Nationwide Population-Based Cohort Study |
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