Nectriatide, a Potentiator of Amphotericin B Activity from Nectriaceae sp. BF-0114

A new compound, designated nectriatide (1), was isolated as a potentiator of amphotericin B (AmB) activity against Candida albicans from the culture broth of Nectriaceae sp. BF-0114. This structure was elucidated based on spectroscopic analyses (1D and 2D NMR data), chemical methods, and total synth...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2019-10, Vol.82 (10), p.2673-2681
Main Authors: Fukuda, Takashi, Nagai, Kenichiro, Yagi, Akiho, Kobayashi, Keisuke, Uchida, Ryuji, Yasuhara, Tadashi, Tomoda, Hiroshi
Format: Article
Language:English
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Summary:A new compound, designated nectriatide (1), was isolated as a potentiator of amphotericin B (AmB) activity against Candida albicans from the culture broth of Nectriaceae sp. BF-0114. This structure was elucidated based on spectroscopic analyses (1D and 2D NMR data), chemical methods, and total synthesis. Compound 1 was a unique cyclotetrapeptide consisting of l-N-methyltyrosine, anthranilic acid, l-alanine, and l-valine. Compound 1 and several synthetic derivatives, including linear peptides, potentiated AmB activity against C. albicans by up to 16-fold (the MIC value of AmB decreased from 0.5 μg/mL to 0.031 μg/mL in combination with test compound).
ISSN:0163-3864
1520-6025
DOI:10.1021/acs.jnatprod.8b01056