Hepatoprotective Effect of Neonatal Administration of Non-Opioid Leu-Enkephalin Analogue in Adult Albino Rats Subjected to Antenatal Hypoxia

• Published in: Bulletin of experimental biology and medicine 2019-08, Vol.167 (4), p.428-431
• Main Authors: Pinaeva, O. G., Lebed’ko, O. A., Pinaev, S. K., Sazonova, E. N.
• Format: Article
• Language: English
• Subjects: Albinism; Animals; Antioxidants; Biological products; Biomedical and Life Sciences; Biomedicine; Body weight; Body Weight - drug effects; Cell Biology; Enkephalin (leucine); Enkephalin, Leucine - analogs & derivatives; Enkephalin, Leucine - therapeutic use; Enkephalins; Female; General Pathology and Pathophysiology; Hepatocytes; Hepatocytes - drug effects; Hypoxia; Hypoxia - drug therapy; Internal Medicine; Laboratory Medicine; Liver; Liver - drug effects; Male; Narcotics; Neonates; Nucleoli; Opioids; Oxidation-Reduction - drug effects; Pathology; Peptides; Pregnancy; Random Allocation; Rats; Rats, Wistar; Rodents
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-019-04542-9

We studied the effects of neonatal administration of non-opioid leu-enkephalin analogue peptide NALE) on the morphological parameters of the liver and redox status of 60-dayold albino rats subjected to antenatal hypoxia. In animals subjected to antenatal hypoxia, a decrease body weight and reduction of the area of hepatocytes and total area of their nucleoli were observed; these changes were accompanied by activation of free-radical processes and impairment of antioxidant defense in the liver and blood serum. Intraperitoneal administration of NALE (100 μg/kg, daily) during postnatal days 2-6 normalized body weight, hepatocyte area, and total area of their nucleoli, significantly reduced the intensity of ROS generation, and improved antioxidant protection in the liver and blood serum in 60-day-old animals subjected to antenatal hypoxia.