Hepatoprotective Effect of Neonatal Administration of Non-Opioid Leu-Enkephalin Analogue in Adult Albino Rats Subjected to Antenatal Hypoxia

We studied the effects of neonatal administration of non-opioid leu-enkephalin analogue peptide NALE) on the morphological parameters of the liver and redox status of 60-dayold albino rats subjected to antenatal hypoxia. In animals subjected to antenatal hypoxia, a decrease body weight and reduction...

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Published in:Bulletin of experimental biology and medicine 2019-08, Vol.167 (4), p.428-431
Main Authors: Pinaeva, O. G., Lebed’ko, O. A., Pinaev, S. K., Sazonova, E. N.
Format: Article
Language:English
Subjects:
Albinism
Animals
Antioxidants
Biological products
Biomedical and Life Sciences
Biomedicine
Body weight
Body Weight - drug effects
Cell Biology
Enkephalin (leucine)
Enkephalin, Leucine - analogs & derivatives
Enkephalin, Leucine - therapeutic use
Enkephalins
Female
General Pathology and Pathophysiology
Hepatocytes
Hepatocytes - drug effects
Hypoxia
Hypoxia - drug therapy
Internal Medicine
Laboratory Medicine
Liver
Liver - drug effects
Male
Narcotics
Neonates
Nucleoli
Opioids
Oxidation-Reduction - drug effects
Pathology
Peptides
Pregnancy
Random Allocation
Rats
Rats, Wistar
Rodents
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Sazonova, E. N.
description We studied the effects of neonatal administration of non-opioid leu-enkephalin analogue peptide NALE) on the morphological parameters of the liver and redox status of 60-dayold albino rats subjected to antenatal hypoxia. In animals subjected to antenatal hypoxia, a decrease body weight and reduction of the area of hepatocytes and total area of their nucleoli were observed; these changes were accompanied by activation of free-radical processes and impairment of antioxidant defense in the liver and blood serum. Intraperitoneal administration of NALE (100 μg/kg, daily) during postnatal days 2-6 normalized body weight, hepatocyte area, and total area of their nucleoli, significantly reduced the intensity of ROS generation, and improved antioxidant protection in the liver and blood serum in 60-day-old animals subjected to antenatal hypoxia.
doi_str_mv 10.1007/s10517-019-04542-9
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ispartof Bulletin of experimental biology and medicine, 2019-08, Vol.167 (4), p.428-431
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source Springer Nature
subjects Albinism
Animals
Antioxidants
Biological products
Biomedical and Life Sciences
Biomedicine
Body weight
Body Weight - drug effects
Cell Biology
Enkephalin (leucine)
Enkephalin, Leucine - analogs & derivatives
Enkephalin, Leucine - therapeutic use
Enkephalins
Female
General Pathology and Pathophysiology
Hepatocytes
Hepatocytes - drug effects
Hypoxia
Hypoxia - drug therapy
Internal Medicine
Laboratory Medicine
Liver
Liver - drug effects
Male
Narcotics
Neonates
Nucleoli
Opioids
Oxidation-Reduction - drug effects
Pathology
Peptides
Pregnancy
Random Allocation
Rats
Rats, Wistar
Rodents
title Hepatoprotective Effect of Neonatal Administration of Non-Opioid Leu-Enkephalin Analogue in Adult Albino Rats Subjected to Antenatal Hypoxia
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